Dipeptide Diaminobutyroyl CAS 823202-99-9

SYN-AKE Introduction

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Dipeptide Diaminobutyroyl is a small peptide that mimics the activity of snake venom toxins, rather than being snake venom itself. It is an active peptide with a structure similar to that of snake venom toxins. The anti-wrinkle effect of this snake-like peptide is five times that of botulinum toxin. Human tests have shown that after 28 days of use, it can effectively reduce wrinkles by 52%. Its CAS number: 823202-99-9; molecular formula: C19H29N5O3.2(C2H4O2); molecular weight: 495.58; EINECS number: 232-697-4

What is the purpose of SYN-AKE?

Dipeptide Diaminobutyroyl is a commonly used topical anti-wrinkle active ingredient in skin care products. It mainly improves the dynamic lines formed by repeated facial expressions, such as crow's feet, glabella lines, and forehead lines.
SYN-AKE does not rely on filling or moisturizing to reduce lines. Its principle is to competitively bind with the muscle nicotine Acetylcholine receptor, moderately weakening the nerve's transmission of contraction signals and reducing the contraction frequency of the expression muscles. The skin can still make natural expressions, but the lines caused by the expressions will gradually be relieved.
Relevant test data shows that when the formula containing this ingredient is applied for about 15 minutes, the skin can show immediate smoothness; if used continuously for 12 weeks, the depth of wrinkles can decrease by 22% and the volume of wrinkles can be reduced by 17%. In addition, this ingredient also has certain antioxidant properties.
Therefore, it is often added to anti-aging essences, eye creams, and face creams. As a mild and reversible solution for skin care, its action logic is similar to botulinum toxin, used to prevent and improve various expression lines.

Since SYN-AKE is described as "snake venom-like", why wouldn't it cause poisoning if applied to the face as it would if it were actually snake venom?

The dipeptide Diaminobutyroyl merely mimics the specific mechanism of action at the outermost layer of the venom of snakes, rather than its entire toxicity.
Specifically, our facial wrinkles are caused by the repeated contraction of facial muscles, and this contraction requires nerve cells to release a signaling molecule called "Acetylcholine" to "command" the muscle cells. The function of SYN-AKE is to imitate the snake venom peptide Waglerin I and bind to Acetylcholine on the muscle cells. It will occupy the receptor position first, preventing the actual Acetylcholine signal from being transmitted, thereby partially and reversibly blocking this contraction command.
However, the SYN-AKE in skin care products is applied externally and its molecular weight is small (about 500 daltons), but the skin barrier will limit its penetration depth. The amount that can reach the nerve-muscle junction is very limited, far from achieving the level of "paralysis", and can only have the effect of slowing down the frequency of muscle contraction and relaxing the expression. In contrast, when bitten by a snake, it is different. The venom enters the bloodstream directly through the wound, and a large amount of toxins can quickly and strongly block the nerve signals, causing complete muscle paralysis and even respiratory failure. Therefore, there are huge differences in the depth of action, intensity and safety between the two.

MF of SYN-AKE

CAS	823202-99-9
Molecular formula	C19H29N5O3.2(C2H4O2)
Molecular weight	495.58
EINECS	232-697-4

Specification

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FAQ: 

Q1:Is SYN-AKE effective in reducing "neck wrinkles"?
For dynamic neck lines caused by tension in the neck muscles, it has a certain auxiliary relaxation effect. However, most neck lines are of the structural and static type (such as skin relaxation, fat accumulation, and collagen loss), and this ingredient is basically powerless against them.
Q2:Will the facial expressions become stiff after using it?

No. The topical application dosage is far from being sufficient to achieve a "numbing" effect. It merely slows down the frequency of muscle contractions rather than completely blocking them. You can still make facial expressions normally, but the "peak" of the dynamic lines has been somewhat flattened, and there will be absolutely no sensation of "facial paralysis".

Q3:Does a higher concentration always mean a better effect?

No. At an addition amount of 0.01% - 0.05%, it has already reached a plateau. Any higher and the effect will not increase linearly; instead, it may increase the complexity of the formula and the cost. The key lies in the overall penetration system and compounding logic of the formula, rather than just the concentration figures.

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