what is H-PRO-LEU-GLY-NH2?
H-Pro-Leu-Gly-NH2 (Cas200-44-0) is an endogenous tripeptide with good water solubility. MF C₁₃H₂₄N₄O₃, MW 284.35, Mainly derived from the hypothalamus, it is a product of oxytocin enzymatic hydrolysis and can effectively inhibit the release of melanocyte stimulating hormone. As a dopamine receptor allosteric modulator, this white powder can act on the nervous system, regulating melanin formation and opioid receptor activity. Due to its ability to directly pass through the blood-brain barrier, it is widely used in neuroscience research and peptide biochemistry.
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Product name |
H-PRO-LEU-GLY-NH2 |
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CAS |
2002-44-0 | |
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Molecular formula |
C13H24N4O3 |
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| EINECS | 217-902-7 | |
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Molecular weight |
284.35 | |
| Melting point | 122-123 °C | |
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Appearance |
white powder |
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| Storage | 2-8℃ |
What are the main uses of H-PRO-LEU-GLY-NH2?
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Treatment of pigmentary skin diseases MIF-1 can be used to treat pigmentation related diseases such as melasma and freckles by inhibiting the activity of melanocytes and reducing melanin production. Its mechanism of action may be related to regulating tyrosinase activity or inhibiting melanocyte proliferation. Skin whitening and anti-aging In the field of beauty, H-PRO-LEU-GLY-NH2 has been studied for the development of whitening products, improving uneven skin tone by inhibiting melanin synthesis. Some studies suggest that it may be related to antioxidant and delaying photoaging. |
Immune regulation assistance
MIF-1 has immunomodulatory functions and may assist in the treatment of skin diseases associated with immune abnormalities, such as psoriasis, but further clinical validation is needed.
Drug development targets
In scientific research, MIF-1 is used as a potential target for the melanin production pathway to screen for novel inhibitors or develop combination therapy regimens.
Basic research tools
In the laboratory, MIF-1 is used as a tool molecule to study the mechanisms of melanocyte differentiation and pigment metabolism, helping to understand the pathology of related diseases.
Product Specification
| Items | Specifications |
Result |
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Appearance |
White powder |
Conforms |
| Loss on Drying |
5% MAX |
2.3% |
| Residue on Ignition | 1.0% MAX | 0.3% |
| Acetate | 12.0%MAX | 5.1% |
| Heavy metals | 10ppm MAX | Conforms |
| Purity | 98% MIN | 99.1% |
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What are the synthesis paths of H-PRO-LEU-GLY-NH2?
chemical synthesis
Peptide synthesis method: Construct amino acid sequences through solid-phase synthesis (SPPS) or liquid-phase synthesis. And optimize the coupling reaction conditions using Fmoc or Boc protecting groups
biosynthesis
Gene recombination technology: Insert the gene encoding H-PRO-LEU-GLY-NH2 into an expression vector (such as pET series plasmid), express it in Escherichia coli or yeast, and remove impurities through HPLC, affinity chromatography and other techniques to ensure product purity.
Company profile
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q: Is H-Pro-Leu-Gly-NH2 safe?
A:In the cosmetics industry, MIF-1 is usually considered a low-risk ingredient, but individual differences should be noted. Some studies have shown that low concentrations may cause mild skin irritation (such as redness, swelling, and itching), and sensitive skin should be treated with caution
Q: How long is its half-life in the body?
A: An early rat study showed that its half-life is only about 9 minutes.
Q: What are the main degradation products of MIF-1 in the body?
A: Human plasma rapidly inactivates it, with the main degradation products being leucine glycine amine (Leu-Gly-NH2) and proline.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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