Acetyl Hexapeptide 38 CAS 1400634-44-7

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Acetyl hexapeptide 38 (breast enhancement peptide) is an acetylated hexapeptide, which can significantly stimulate the synthesis of fat in the use site, increase the volume of the chest or cheeks, and shape a perfect figure. CAS：1400634-44-7.Studies have shown that 98% purity acetyl hexapeptide -38 powder is white powder, which can stimulate the expression of peroxisome proliferator-activated receptor γ coactivator -1α(PGC-1α), promote the rate of fat production and increase the volume of adipose tissue in specific parts.

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What are the related studies on Acetyl hexapeptide 38?

The culture experiment of preadipocytes showed that after 10 days, the preadipocytes were induced with 0.5mg/ml of acetyl hexapeptide 38, in which the expression of PGC-1α increased by 61.1% and the fat accumulation increased by 32.4%. Clinical studies have found that acetyl-hexapeptide-38 has similar effects to botulinum toxin. However, it can avoid a series of side effects of botulinum toxin, including but not limited to pain caused by puncture, erythema, edema and eye ptosis, facial asymmetry and difficulty in speaking caused by toxin diffusion. In addition, It also has the advantages of convenient use and low cost.

What is the clinical effect of Acetyl hexapeptide 38?

30 female subjects, aged between 25 and 45, were recruited from the University of Newston, USA, Chest size: (80-90) B cups, 15 in the placebo group and 15 in the administration group (containing 500PPM of acetyl hexapeptide cream). The experiment lasted for 8 weeks, and it began to take effect in the second week. In the eighth week, the fat volume of the administration group was 30 times higher than that of the placebo group.
The research team believes that disordered neurotransmitters are transmitted to muscles, which makes the contraction of muscles unable to recover normally, and then produces various wrinkles, including wrinkles. Neurotransmitters are synthesized in the cell body of neurons and stored in synaptic vesicles. When stimulated by external environment, a calcium-dependent extracellular secretion (called SNARE protein complex) causes synaptic vesicles to release neurotransmitters, which reach the postsynaptic membrane through synaptic cleft and combine with corresponding receptors. The structure of Acetyl hexapeptide 38 is similar to SNAP-25. (SNARE is a combination of three protein VAMP, Syntaxin and SNAP-25. Therefore, he can compete with SNAP-25 to occupy the position of SNAP-25 in the SNARE combination, thus inhibiting the formation of SNARE, making muscles unable to effectively accept neurotransmitters, limiting muscle contraction, and finally preventing skin wrinkles. In addition, excessive release of catecholamine can also cause wrinkles. However, with the increase of age, many people will be forced to supplement levodopa because of various mental diseases. Therefore, many patients are supplemented with Acetyl hexapeptide 38 to ensure their appearance is more spiritual.

What are the adverse reactions about Acetyl hexapeptide 38?

At the conventional addition concentration of cosmetics, Acetyl hexapeptide 38 is generally mild and there are no public reports of serious adverse reactions.
Only a small number of people with fragile skin barrier and high sensitivity may experience temporary redness and mild itching. Most skin irritations usually come from fragrances, alcohols, and high-concentration acidic additives in the formula, rather than the peptide raw material itself. Excessive addition of the formula will also increase the probability of skin discomfort. It does not clog pores and is not prone to causing acne.
At present, there are no complete safety assessment data for pregnant and lactating groups. Such groups are not recommended to use this ingredient. This component is only suitable for external use on the skin and must not be taken orally. The relevant conclusions are all based on public literature materials and cannot be equated with the results of complete human safety tests.

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FAQ:

Q1:Can one truly achieve facial plumping?
Both in vitro and in vivo clinical tests have shown a slight increase in subcutaneous fat; however, due to the limitations of skin barrier permeability, the effect is mild and limited, and it cannot achieve the aesthetic filling effect. Do not exaggerate the promotion.
Q2:Which types of skin care products are suitable for me?

It is commonly used in anti-aging serums, creams, eye creams, as well as in formulations for facial plumping and lip care; it is suitable for aqueous and cream-based systems. The recommended pH range for the formula is 4 - 7.2 for better stability.

Q3:How long will it take to see the changes in the skin?

It is a long-term and mild active ingredient. If used consistently, a noticeable improvement in skin fullness can be observed after 28 to 56 days. There is no immediate filling effect upon application.

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