Acetyl Hexapeptide 38 CAS 1400634-44-7

Acetyl hexapeptide 38 (breast enhancement peptide) is an acetylated hexapeptide, which can significantly stimulate the synthesis of fat in the use site, increase the volume of the chest or cheeks, and shape a perfect figure. Studies have shown that 98% purity acetyl hexapeptide -38 powder is white powder, which can stimulate the expression of peroxisome proliferator-activated receptor γ coactivator -1α(PGC-1α), promote the rate of fat production and increase the volume of adipose tissue in specific parts.

What are the related studies on Acetyl hexapeptide 38?

The culture experiment of preadipocytes showed that after 10 days, the preadipocytes were induced with 0.5mg/ml of acetyl hexapeptide 38, in which the expression of PGC-1α increased by 61.1% and the fat accumulation increased by 32.4%. Clinical studies have found that acetyl-hexapeptide-38 has similar effects to botulinum toxin. However, it can avoid a series of side effects of botulinum toxin, including but not limited to pain caused by puncture, erythema, edema and eye ptosis, facial asymmetry and difficulty in speaking caused by toxin diffusion. In addition, It also has the advantages of convenient use and low cost.

What is the clinical effect of Acetyl hexapeptide 38?

30 female subjects, aged between 25 and 45, were recruited from the University of Newston, USA, Chest size: (80-90) B cups, 15 in the placebo group and 15 in the administration group (containing 500PPM of acetyl hexapeptide cream). The experiment lasted for 8 weeks, and it began to take effect in the second week. In the eighth week, the fat volume of the administration group was 30 times higher than that of the placebo group.
The research team believes that disordered neurotransmitters are transmitted to muscles, which makes the contraction of muscles unable to recover normally, and then produces various wrinkles, including wrinkles. Neurotransmitters are synthesized in the cell body of neurons and stored in synaptic vesicles. When stimulated by external environment, a calcium-dependent extracellular secretion (called SNARE protein complex) causes synaptic vesicles to release neurotransmitters, which reach the postsynaptic membrane through synaptic cleft and combine with corresponding receptors. The structure of Acetyl hexapeptide 38 is similar to SNAP-25. (SNARE is a combination of three protein VAMP, Syntaxin and SNAP-25. Therefore, he can compete with SNAP-25 to occupy the position of SNAP-25 in the SNARE combination, thus inhibiting the formation of SNARE, making muscles unable to effectively accept neurotransmitters, limiting muscle contraction, and finally preventing skin wrinkles. In addition, excessive release of catecholamine can also cause wrinkles. However, with the increase of age, many people will be forced to supplement levodopa because of various mental diseases. Therefore, many patients are supplemented with Acetyl hexapeptide 38 to ensure their appearance is more spiritual.

What are the adverse reactions about Acetyl hexapeptide 38?

Acetyl hexapeptide -38 is a synthetic peptide component, which is often used in skin care products, mainly aiming at dynamic lines and skin relaxation. At present, there are few clinical studies on its side effects, but based on its mechanism of action and practical application feedback, the possible side effects include mild skin irritation, redness or itching, which are usually related to individual sensitivity or improper use.
1. The function and safety of acetyl hexapeptide 38
Acetyl hexapeptide -38 reduces muscle contraction by simulating the effect of botulinum toxin (inhibiting the release of neurotransmitters), thus diluting expression lines. Because of its small molecular weight and mild action, most people have no obvious side effects after using it. However, it should still be noted that the skin with damaged sensitive muscles or barriers may cause local irritation due to increased permeability; High concentration or frequent overuse may destroy the normal metabolism of the skin, leading to dryness or peeling.
2. Potential side effects that have been reported so far.
Local irritation: such as tingling and burning sensation, it is more common when used for the first time or with other irritating ingredients (such as acids and retinol).
Transient redness or swelling: it may be related to the skin's immune response to peptide components, which usually subsides within a few hours.
Allergy risk: Very few people are allergic to synthetic peptides, showing persistent erythema, rash or itching, and need to stop using them immediately.
In addition, because the safety research of acetyl hexapeptide-38 powder is mostly based on in vitro experiments or short-term human trials, the safety of long-term use still needs more data support. Some experts believe that its mechanism may affect the transmission of nerve signals, but there is no evidence that it will cause systemic risks, so we should pay attention to the following points when using it:
1. Test tolerance: Before the first use, conduct a 24-hour local test behind the ear or inside the wrist.
2. Avoid overlapping irritating ingredients: If it is used together with high-concentration acids and exfoliating products, it may aggravate irritation.
3. Control the frequency of use: it is recommended to start from 2-3 times a week and gradually transition to daily use.
4. Use with caution for special people: pregnant women, lactating women and severely sensitive muscles need to consult a doctor.

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