The biggest difference between paracetamol and ibuprofen in terms of therapeutic effects lies in whether they have anti-inflammatory effects, because I believe many people want to know whether these two products can be replaced for their intersecting functions in our daily use.
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| 15687-27-1 Ibuprofen | 103-90-2 Acetaminophenol |
1：Comparison of physical properties between them
The trade name of acetaminophen is paracetamol, which belongs to acetanilide antipyretic and analgesic drugs. Its appearance is white crystal or crystalline powder, melting point is 168 ~ 172℃, odorless, slightly bitter, soluble in hot water or ethanol, soluble in acetone, almost insoluble in cold water and petroleum ether. It is stable below 45℃, but if exposed to humid air, it will be hydrolyzed into p-aminophenol, and then further oxidized, and the color will gradually turn pink, brown and finally black, so it should be kept in a cold and dry place.
Ibuprofen is a non steroidal anti-inflammatory and analgesic drug. White crystalline powder. Melting point 75-77 ℃. Insoluble in water, easily soluble in ethanol, chloroform, ether, and acetone. It has a foul odor and is odorless. This product has good anti-inflammatory, analgesic, and antipyretic effects with minimal adverse reactions.
2：Comparison of pharmacological effects
Acetaminophen has antipyretic effect by inhibiting the synthesis of prostaglandin in hypothalamic thermoregulation center, and its antipyretic effect is similar to that of aspirin. It has analgesic effect by inhibiting the synthesis of prostaglandin in central nervous system and blocking the impulse of pain nerve endings, and its effect is weaker than that of aspirin, with the advantages of less irritation and little allergic reaction, and its antipyretic and analgesic effect is similar to that of phenacetin.
Ibuprofen can inhibit the metabolism of tetraenoic acid by cyclooxygenase in cell membrane into inflammatory mediator prostaglandin, thus alleviating local tissue congestion and swelling caused by prostaglandin. It also reduces the pain sensitivity of local peripheral nerves to bradykinin and plays an anti-inflammatory and analgesic role. Prostaglandin is also a strong pyrogen, which can also play an antipyretic role when it is inhibited. In addition, it also has a certain scavenging effect on other components that cause inflammatory reaction, such as oxygen ions and superoxide radicals.
Although their goal is to control prostaglandin, the path is completely different: ibuprofen generally relieves inflammation by controlling prostaglandin produced by human body, that is, non-selectively inhibiting COX-2 from synthesizing prostaglandin or other inflammatory factors; Acetaminophen usually has antipyretic and analgesic effects by inhibiting the synthesis of prostaglandin by COX-3 in the central nervous system.
3：Comparison of clinical application between them.
It should be noted that ibuprofen is generally metabolized in the kidney, and the main metabolic site of acetaminophen is the liver. In summary, the different mechanisms (pathways) mentioned above lead to different adverse reactions, among which most of the side effects of ibuprofen are digestive tract reactions, such as nausea, stomachache, indigestion, etc. However, acetaminophen can cause allergic dermatitis, anemia, thrombocytopenia and other side effects. In terms of fever and analgesia, the safety and effectiveness of the two drugs are equivalent and can be replaced. However, long-term large-scale use of paracetamol may cause liver damage, and long-term large-scale use of ibuprofen may cause serious gastrointestinal reactions, such as digestive tract ulcer, bleeding and other diseases. Therefore, we should pay attention to the difference of their side effects when replacing them, and use drugs carefully.
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