What Is Carprofen?

Usually, Carprofen refers to compound acetaminophen tablets. The drug has antipyretic and analgesic effects, and is mainly used to relieve fever, headache and other symptoms caused by common cold or influenza in clinic.

The Carprofen Mystery?

Generally, Carprofen is considered to be a compound preparation of acetaminophen, which has antipyretic and analgesic effects. Therefore, it is often used to relieve fever, headache and other symptoms caused by common cold or influenza. Some people also believe that the main ingredient of Carprofen is sodium diclofenac. Such chaotic information makes it difficult for many people to understand.

What is the difference between Carprofen and acetaminophen and diclofenac sodium?

Non steroidal anti-inflammatory drugs (NSAIDs) are widely used in clinical practice. It has anti-inflammatory effects and can be used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout; It has analgesic effects and can be used for headaches, migraines, toothache, menstrual pain, and postoperative pain; It has antipyretic effects and can be used for fever caused by diseases such as colds, acute upper respiratory infections, and acute pharyngitis.

As commonly used nonsteroidal anti-inflammatory drugs in clinical practice, the differences between diclofenac, ibuprofen, and acetaminophen are as follows:

1：Drug contraindications are a concentrated manifestation of adverse drug reactions.

first, let's learn about aspirin asthma.
Some patients may experience severe asthma, laryngeal edema, urticaria, hypotension, and shock after taking aspirin for minutes or hours. This phenomenon is called aspirin asthma (aspirin hypersensitivity).
There are considerable cross reactions between aspirin and other NSAIDs, so it is generally recommended that patients with hypersensitivity to aspirin or any other NSAIDs avoid using all NSAIDs.
However, for patients who are sensitive to aspirin, acetaminophen is usually safe to use.
Secondly, let's understand the hepatotoxicity of acetaminophen.
Excessive oral intake of acetaminophen can cause fatal liver damage. The maximum daily dose of acetaminophen for adults specified by the US FDA is 4g, while the maximum daily dose for adults specified in the Chinese Pharmacopoeia Clinical Medication Guidelines is 2g.
Diclofenac acid and ibuprofen also have certain liver toxicity. Local external application of diclofenac gel and cream can be absorbed by the whole body, and can also cause the elevation of transaminase. Long term and large-scale use should be avoided.

2： Is diclofenac associated with the highest cardiovascular risk?
Non steroidal anti-inflammatory drugs exert anti-inflammatory, antipyretic, and analgesic effects by inhibiting cyclooxygenase (COX).
Cyclooxygenase (COX) is an enzyme necessary for the synthesis of prostaglandins (PGs), including three isoenzymes, COX-1,COX-2,COX-3.
We can classify NSAIDs into three categories based on their selectivity for COX: non selective COX inhibitors such as indomethacin, nalbutanone, ibuprofen, etc; Selective COX-2 inhibitors, such as celecoxib and etoposide; Selective COX-3 inhibitors, such as acetaminophen.

3： Can ibuprofen be used in combination with aspirin?
When ibuprofen is used in combination with aspirin, it can competitively occupy the acetylation site of platelet COX-1, weaken the antiplatelet aggregation effect of aspirin, and increase the risk of cardiovascular events.

If it is necessary to take ibuprofen, the effect of ibuprofen on aspirin antiplatelet activity can be reduced by adjusting the medication interval.
Ibuprofen is easily absorbed when taken orally, with a peak blood concentration of 1-2 hours after administration and a half-life of 1.8-2 hours. Therefore, in order to reduce the impact of ibuprofen on low-dose aspirin:
1. Aspirin tablets: Take ibuprofen 8 hours or 30 minutes before taking aspirin;
2. Aspirin enteric coated tablets: Aspirin enteric coated tablets have slow absorption, and ibuprofen should be taken 5 hours before or 5 hours after taking enteric coated aspirin.
reminder:
Acetaminophen and diclofenac do not affect the antiplatelet aggregation effect of aspirin.

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