According to official Chinese media reports, experts from the Organ Transplantation Center of the First Affiliated Hospital of Sun Yat sen University, in collaboration with an international team, have successfully revived an ex vivo pig brain that had been "dead" for 50 minutes using the world's first "ex vivo brain care technology".
Basic research on pig brain resurrection
During the process of checking the progress of the relevant experiments, we found that the research had already begun and was published as a cover article in the international journal Molecular Medicine of the European Organization for Molecular Biology on September 19th
According to the article, they observed a whole brain ischemia model in vivo and found that compared with the brain without concurrent liver ischemia, the reperfusion brain with concurrent liver ischemia had a larger infarct area, higher tissue damage score, and increased adhesion of CD45+cells in the blood vessels.
In an in vitro brain room temperature machine perfusion (NMP) model, adding a normally functioning liver to the NMP circulation can significantly reduce postoperative brain injury, increase neuronal activity, and improve brain electrical activity. In addition, significant changes were observed in both transcriptome and metabolome with or without liver ischemia.
This study emphasizes the crucial role of the liver in the pathogenesis of postoperative brain injury. This provides important clues for developing new treatment methods that can simultaneously target the liver and brain to improve the prognosis of patients after cardiac arrest.
The research process of pig brain resurrection!
Researchers used pigs as experimental subjects, first stopping their hearts, and then separating their brains from their bodies. After 50 minutes, the researchers connected the detached brain to an extracorporeal life support device through a catheter, forming a life system that supports brain recovery.
This device adopts the team's independently developed "ex vivo brain maintenance technology", which not only contains artificial heart and artificial lung components, but also uses blood perfusion technology at room temperature to maintain a live pig liver, providing fresh, aerobic, and metabolically stable blood circulation for the ex vivo pig brain connected to the device.
The results showed that the pig's brain was successfully 'revived', able to restore brain function and maintain vitality for a certain period of time. The research team voluntarily terminated the experiment after 6 hours.
Research has shown that with the support of a simple cardiopulmonary resuscitation system, in vitro brain edema is significant, nerve cell vitality is significantly reduced, and brain electrophysiological activity gradually disappears; With the support of the extracorporeal heart lung liver complex life system, the edema of the isolated brain is significantly reduced, the vitality and microstructure of nerve cells are significantly improved, and brain electrical activity can be restored and maintained.
|
|
|
Experts from an organ transplant center in a Chinese hospital stated that the research findings provide a new strategy for rescuing cardiac arrest patients, which is expected to improve the success rate of rescuing cardiac arrest patients in the future and provide a new platform for neuroscience research.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, Please also contact us via Email ：sales6@faithfulbio.com ; Our team is committed to ensuring the complete satisfaction of customers.