Tetramethyluric acid powder belongs to purine heterocyclic alkaloids, and the mother nucleus is formed by the fusion of pyrimidine and imidazole rings to form a planar conjugated bicyclic structure. Four methyl groups are covalently attached to the nitrogen atoms at positions 1, 3, 7, and 9 of the purine skeleton, with three carbonyl groups on the ring. The molecule is a chiral and symmetrical molecule with no optical activity. This fully methyl substituted uric acid skeleton determines the charge distribution, polarity, and receptor binding mode of the molecule. The polar surface area is 70.93, and the number of molecular hydrogen bond donors is extremely low. Therefore, it has weak solubility in water and is more easily dispersed in alcohol organic solvents. The regular conjugated planar structure endows it with good crystallization ability, making it easy to form white crystalline powder under normal conditions. The molecular skeleton is stable and less prone to oxidation and ring opening in dark and low humidity environments. The carbonyl and methyl substitution modes on the ring jointly determine its binding characteristics with adenosine receptors, which is the structural basis of its pharmacological activity. This raw material is only used for formula development and laboratory research, and cannot be directly taken orally. When designing the formula, it is necessary to consider the physical and chemical characteristics brought by its structure, select suitable excipients, and avoid the risk of precipitation caused by improper compatibility.
If you are looking for Tetramethyluric acid powder for laboratory research, Faithful Chemical can provide you with the product.
Tetramethyluric acid powder Description
Tetramethyluric acid powder is a purine alkaloid raw material. It is in the form of white to off white crystalline powder, naturally present in the leaves of bitter tea, and can also be obtained through chemical synthesis. Belonging to methylxanthine derivatives; Due to the presence of an additional methyl group in the molecule, it exhibits different pharmacological properties. This raw material has low solubility in water, but is soluble in certain organic solvents. It has good chemical stability and is often used as a core ingredient in cognitive enhancement and energy supplement formulas. Tetramethyluric acid powder can act on adenosine receptors, producing a mild refreshing and soothing effect. It is not easy to develop rapid tolerance and experiences less fatigue or palpitations after the excitatory effect subsides. This product is only for formula development and related research and development use, and cannot be directly taken as a finished product. When designing the formula, it is necessary to strictly control the dosage and conduct compatibility testing to avoid the risks of overlapping with other stimulating ingredients.
Tetramethyluric acid powder CAS 2309-49-1, also known as bitter theophylline, belongs to the class of methylxanthine purine derivatives. Its mother nucleus is the uric acid skeleton, with four methyl groups attached to the nitrogen atoms at positions 1, 3, 7, and 9 of the purine ring. The saturated methyl substitution mode alters the binding mode between the molecule and adenosine receptors. Tetramethyluric acid powder has an additional methyl group, and this structural difference directly determines its binding affinity with adenosine A1 and A2 receptors. The molecule as a whole is a planar conjugated heterocyclic structure with strong crystallinity, and it appears in powder form under normal conditions. There are significant differences in their transmembrane absorption characteristics. It has fewer hydrogen bond sites and lower solubility in aqueous solutions, making it more suitable for mixed oil-based or composite excipient systems. This special tetramethyl substitution structure allows it to stimulate receptors in a smoother way, making it less likely to cause strong neural arousal rebound
Global Market Description
In the context of market procurement, experienced buyers within supplement compounding and formulation sectors have moved beyond merely considering whether Tetramethyluric acid powder can deliver expected cognitive support effects. They now place greater emphasis on batch consistency, impurity control and long-term storage stability, ensuring that compounding prescription use and formulation development deliver predictable, safe outcomes.
| Category | Details |
| Market trend up to 2026 | The global Tetramethyluric acid powder market keeps stable growing demand |
| Available product form | Purified raw powder for cognitive formulation compounding |
| Advantage of this form | Gentle stimulating effect, low crash risk, easy for custom dose design |
| Applicable scenarios | Nootropic formulation development, energy supplement compounding, cognitive support formula screening, ingredient compatibility testing |
When compounding formulators and formulation laboratories procure this product for applications such as customized dose preparation, new formulation screening and stability testing, they must look past basic pharmacological effect and focus on core quality indicators. This focus is essential for maintaining dosing safety and formulation reliability across different formulation schemes and long-term development plans. In this field, Faithful Chemical possesses a distinct advantage, backed by extensive industry experience.
Three Core Driving Forces
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First, customized nootropic formula demand is rising. Many cognitive support formulation projects need flexible dosage design, and Tetramethyluric acid powder serves as the key raw material for these compounding formulas.
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Second,People awareness of mild excitatory components is increasing day by day. The product development team continues to explore ingredients that neither cause palpitations nor lead to significant energy decline in the future.
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Third, strict quality standard requirements push supply chain upgrade. Buyers require stable impurity profiles and consistent batch test data, which drives qualified suppliers to standardize production and quality control of Tetramethyluric acid powder.
Purchasing Notes For Tetramethyluric acid powder
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Tetramethyluric acid powder is only for formulation and compounding development, not for direct oral consumption. It cannot be sold as a finished ready-to-use product.
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Before shipment, request the complete COA document to verify impurity content, moisture and batch test data, and confirm the test method matches your internal quality standard.
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Store Tetramethyluric acid powder in a sealed, cool, dry and dark environment. Avoid high temperature and humidity to prevent powder degradation and discoloration.
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Pay attention to compounding compatibility. It is a mild stimulant raw material. Do not excessively stack with other excitatory ingredients to avoid overstimulation risks in finished formulas.
Mechanism and Use of Tetramethyluric acid powder
Mechanism of Tetramethyluric acid powder
Tetramethyluric acid powder selectively binds to adenosine receptors in the brain. It blocks adenosine signaling, which helps reduce feelings of fatigue and drowsiness.
It modulates central nervous system activity gently. it produces steady alertness and is less likely to trigger nervousness or sharp post-dose crash.
It supports the balance of neurotransmitters related to focus. This raw material is only for formulation use. Excessive addition in compound formulas may cause overstimulation.
Use of Tetramethyluric acid powder
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It acts as a core active raw material for custom cognitive-support compound formulas, enabling flexible dosage adjustment to match different formulation design requirements.
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It is widely applied in new gentle stimulant formulation development, helping formulators screen suitable excipients and optimize compounding procedures.
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It can be used for formulation stability tests and ingredient compatibility evaluation in laboratory formula development projects.
Questions Buyers Ask Before Placing A Bulk Order
Conclusion and References
Conclusion
Tetramethyluric acid powder is a natural or synthetic methylxanthine ingredient characterized by a unique molecular structure. It provides a mild, long-lasting energizing effect with a lower likelihood of "rebound" fatigue, and the body develops tolerance to it relatively slowly. When sourcing and using tetramethyluric acid powder, it is essential to strictly verify batch quality specifications and adhere to standard storage requirements. This substance is intended exclusively for use in product formulation and development; it is not for direct consumption. During the formulation process, dosage must be carefully controlled, and the compatibility of all ingredients should be tested to mitigate the risk of overstimulation of the nervous system. Through rigorous quality control and standardized formulation practices, the potential of tetramethyluric acid powder can be maximized in products designed to enhance focus and support cognitive function.
Should you have any research or production requirements for Tetramethyluric acid powder
please contact Faithful Chemical:
Email: allen@faithfulbio.com Or WhatsApp: +86 13137770562.
References
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- Li W X, Li Y F, Zhai Y J, Chen W M, Kurihara H, He R R. Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice. Journal of Agricultural and Food Chemistry, 2013, 61(26):6328-6335.
- Qiao H Y, Ye X S, Bai X Y, He J, Li T L, Zhang J, Zhang W K, Xu J K. Theacrine: a purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system. Neuroscience Letters, 2017, 659:48-53.
- Duan W J, Liang L, Pan M H, et al. Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation. Phytomedicine, 2020, 77:153281.
- Sheng Y Y, Xiang J, Wang Z S, Jin J. Theacrine From Camellia kucha and Its Health Beneficial Effects. Frontiers in Nutrition, 2020, 7:596823.
- Wang G E, Li Y F, Zhai Y J, Gong L, Tian J Y, Hong M, Yao N, Wu Y P, Kurihara H, He R R. Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. Metabolism, 2018, 85:227-239.
- Zhang L, Liu Y, Chen Y. Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor. Molecules, 2021, 26(24):7455.