Salvia is rich in polyphenols, which have been proved to have clinical benefits and fascinating preclinical discoveries. But perhaps the most striking benefit of sage is its cognitive protection. In a series of clinical trials, scientists found that young people who took sage extract benefited from improving mood, reducing anxiety, enhancing long-term memory and reducing mental fatigue within a few hours. The researchers also recorded the cognitive benefits of Alzheimer's patients. In a randomized clinical trial of patients with mild to moderate Alzheimer's disease, the cognitive score of the placebo group deteriorated by about 22% within four months. However, the score of the group supplemented with sage extract increased by about 26%. This is a remarkable result.
Know sage extract
However, a new salvia extract can provide more powerful brain protection, which needs more proof to support. In the Mediterranean region of origin, more scientific research institutions generally focus on memory research. In addition, the edible part of sage includes sage oil and extract, which is consistent with the name of spice given in GB 2760. The oil components include eucalyptus oil, borneol, arborvitae ketone, etc., which have refreshing, anti-inflammatory and antibacterial effects, and different receiving seasons also affect the efficacy; Flavonoids and phenols are the main components in the extract, which have antioxidant, memory improving and anti-inflammatory effects, among which rosmarinic acid has a high content. Experiments show that there is no essential difference between them, and the difference in efficacy is mainly caused by the different use parts and harvesting time.
The cognitive benefits of sage go beyond traditional medicine.
Slight deterioration of brain function is called mild cognitive impairment. It will affect memory, attention and other psychological processes. More serious losses are considered dementia, including Alzheimer's disease. Alzheimer's disease and other forms of dementia are partly characterized by low levels of neurotransmitter acetylcholine. Losing memory and brain power is not a "part of life" that everyone must endure. Studies have shown that certain nutrients help to maximize brain function. Salvia herb stands out because of its ability to protect neurons and enhance cognitive function.
Scientists have found that sage extract can improve the memory of the elderly by nearly 60% and improve their attention by 2.5 times within a few hours after ingestion.
This new extract has neuroprotective ability that other preparations do not have, and it is shown that it can prolong the life of aging animal models by 12%.
Sage extract can help support brain health, especially when taken with other brain-beneficial supplements.
How does sage work?
1. Improve lipid metabolism and insulin signal.
In a striking preclinical analysis, it was found that Salvia extract can increase the expression of genes related to lipid metabolism and insulin signaling-both of which are related to prolonging life. Blood tests in the elderly usually show an increased risk of glucose, cholesterol and triglycerides. In the aging model using ascaris lumbricoides, this extract prolongs the life span by 12%. Other sources of experimenters did not prolong life.
2. Stronger neurotransmitter signal
In addition to the increase of acetylcholine level caused by other salvia sources, this extract can also enhance the activity of other neurotransmitters, such as GABA(γ- aminobutyric acid) and glutamic acid. This helps to explain the profound cognitive benefits observed in human research.
3. Increased blood flow to the brain
As we get older, the blood flow in our brain will decrease due to hardening of blood vessels and damage to the fragile capillary bed. This new sage extract has vasodilatory properties, which means that it can open blood vessels that provide important blood and oxygen to the brain. Age-related decrease in blood flow is a precursor to memory loss and dementia.
Market application of Salvia extract
In ancient Europe, sage is a common kitchen plant and medicinal plant. It is not only a seasoning, but also an aromatic vegetable. In China, it is a common folk herb, which has the functions of promoting blood circulation, removing blood stasis, dredging menstruation, relieving pain, clearing heart fire, relieving irregular menstruation and so on.
Studies have shown that some middle-aged and elderly people have a lot of free calcium attached to the surface of synapses due to the entanglement of neurons and the loss of cholinergic neurons in brain tissue, which leads to poor nerve impulse transmission. Salvia extract can inhibit the activity of acetylcholinesterase, increase the concentration of acetylcholine in the brain, and acetylcholine reacts with free calcium, thus protecting the smoothness of nerve transmission.
According to the data released by Acute Market Reports in April 2017, the global market for brain health nutrition products is expected to reach $11.6 billion by 2024, and will maintain a compound annual growth rate of 19.6% from 2016 to 2024.
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