betulinic acid powder(BA) is a natural pentacyclic triterpenoid compound with a clear core active structure and a wide range of biological functions. It is a representative molecule among plant derived anti-tumor and anti-inflammatory lead compounds.
It was first isolated from the bark of birch trees in 1788, with the chemical name 3 β - hydroxy-20 (29) - lupene-28-carboxylic acid, CAS number 472-15-1, molecular formula C ∝₀₄₈ O ∝, and molecular weight 456.7. Its structural feature is a rigid skeleton consisting of one five membered ring and four six membered rings, with a key pharmacophore composed of a hydroxyl group at position 3 and a carboxyl group at position 28, giving it high targeting and low cytotoxicity advantages.
🌲 Natural sources and extraction logic
BA is not an artificially synthesized product, but widely exists in various plants, with significant differences in content:
Main source: bark of Betula spp., especially Betula pubescens and B. pendula, which are the most abundant in Europe, accounting for 10-45% of dry weight and mainly enriched in the outer cork tissue;
Secondary sources: papaya, rosemary, Pulsatilla, Zizyphus spinosae, etc., but the content is usually less than 1%;
Biological synthesis pathway: Plants generate isopentenyl pyrophosphate (IPP) through the pathway of methylglutaric acid (MVA) or methylerythritol phosphate (MEP), which is then cyclized with squalene to form betulin and ultimately oxidized to BA.
It is worth noting that BA often coexists with the precursor betulin, and both require precise regulation of oxidation conditions in the extraction process to achieve high selectivity conversion. In industry, the route of "birch bark → ethanol/acetone reflux extraction → silica gel column chromatography → recrystallization purification" is commonly used to obtain white to light yellow powders with HPLC purity of ≥ 98%.
🧪 Physical and chemical properties determine the use of boundaries
The physical and chemical parameters of BA powder are directly related to its solubility, stability, and formulation compatibility:
| parameter | numerical value | Instructions |
| appearance | White to light yellow powder symbol | Medical grade and scientific grade appearance standards |
| melting point | 295-298 ° C (decomposition) | High melting point reflects strong intermolecular hydrogen bonds and good thermal stability |
| solubility | Easily soluble in DMSO (≥ 10 mg/mL) and acetic acid; Slightly soluble in water and ethanol | Poor water solubility is the main reason for its limited oral bioavailability |
| stability | Solid can be stored for 2 years at 2-8 ° C; Mother liquor -20 ° C in January, -80 ° C in June | Temperature and light sensitivity require sealed storage away from light |
| LogP | ~7.09 | Highly lipophilic, beneficial for penetrating cell membranes, but also increases the difficulty of metabolic clearance |
(Additional explanation): A LogP value of 7.09 indicates that BA has strong hydrophobicity, which is not only its advantage of easy entry into cells, but also the technical motivation for developing water-based formulations such as nanoemulsions and liposomes. Currently, research has been conducted to improve lipid solubility and sustained-release performance through Betulinic acid palmitate (CAS 19833-15-9).
🧬 Why does betulinic acid powder become a "star natural active substance"? --Panorama of Mechanism and Efficacy
The core value of betulinic acid powder lies in its multi-target and low toxicity biological activity spectrum, especially in the fields of anti-tumor, anti-inflammatory, and metabolic regulation with solid evidence.
🔬 Key mechanism of action: from molecular targets to pathway regulation
BA is not a single target drug, but achieves physiological effects through multi-level interventions:
Topoisomerase I inhibitor: IC ₅₀=5 μ M, induces DNA damage and S phase arrest by blocking the dissociation of enzyme DNA complexes;
Activation of mitochondrial apoptosis pathway: independent of p53 or CD95, it directly promotes Bax/Bak oligomerization, mitochondrial membrane potential collapse, cytochrome c release, and triggers caspase cascade reaction;
Hh/Gli signaling pathway inhibitor: IC ₅₀=32 μ M, interferes with downstream Gli transcription factor activity in the Hedgehog pathway, inhibits tumor stem cell self-renewal;
Negative regulation of NF - κ B and STAT3 pathways: reduces the expression of inflammatory factors (TNF - α, IL-6) and alleviates the chronic inflammatory microenvironment.
🧪Latest research progress on pharmacological activity of betulinic acid powder
✅Nanodelivery breakthrough: Liposomal encapsulation increased the bioavailability of betulinic acid from 12% to 68%, and increased intestinal absorption rate by 3.2 times. It has been used in phase II clinical trials.
✅New target for gene regulation: Northeast Forestry University has discovered that the BpbHLH42/44 transcription factor can be activated by methyl jasmonate (MeJA), directly upregulating key enzymes in the betulinic acid synthesis pathway, providing a molecular target for high-yield "super birch" breeding.
✅Compound efficiency enhancement scheme: 1:1 combination with VC derivatives, achieving a DPPH scavenging rate of 98.7%; Combined with cinnamon powder and chromium yeast, postprandial blood glucose fluctuations decreased by 37.2%.
🎯Market Prospect Analysis of Betulinic Acid Powder
Betulinic acid powder has a wide range of applications. In the pharmaceutical field, it has inhibitory activity against melanoma, brain tumors, leukemia, etc. The American Cancer Institute has included it in its rapid development plan; In terms of scientific research and quality inspection, betulinic acid powder can be used as a standard and control substance for internal quality analysis of drugs and health products; In the field of cosmetics, with its antioxidant and anti-inflammatory properties, it can delay skin aging and prevent skin inflammation. In the future, more skincare products containing betulinic acid may be developed.
In the future, the betulinic acid powder industry will place greater emphasis on scientific research and technological innovation. For example, improving the extraction efficiency and purity of betulinic acid through biotechnology can reduce costs and expand its application scope. With the global preference for natural ingredients and concerns about synthetic chemicals, betulinic acid, as an active ingredient from natural sources, is expected to gain wider recognition and application in the global market.
However, the betulinic acid powder market also faces some challenges. For example, its extraction technology may not be mature enough, resulting in limited production and high costs; Market competition may also become increasingly fierce. But overall, opportunities outweigh challenges. With the improvement of people's health awareness and the continuous growth of demand for natural products, the market prospects for betulinic acid powder are relatively optimistic. For enterprises, if they can continuously improve their extraction technology, optimize product quality, and expand their application areas, they can occupy a favorable position in the market.
🌟 Conclusion
The latest research of betulinic acid has confirmed that it has strong and selective anti-tumor activity (especially for melanoma and breast cancer), significant anti HIV and influenza virus ability, and plays an anti-inflammatory/antioxidant role through the NF - κ B pathway; Its derivatives, such as 23 hydroxybetulinic acid, have entered phase II clinical trials in the fields of neuroprotection, photoprotection, and nanodelivery.
Betulinic acid powder has surpassed the traditional positioning of traditional Chinese medicine ingredients and become a leading compound with multiple targets and cross disease domains
The most mature anti-cancer direction - NCI in the United States has been included in the rapid research and development plan, and multiple phase II clinical trials are underway;
Antiviral and neuroprotective measures will be the breakthrough point in 2026, especially in the intervention of HIV resistant strains and Alzheimer's disease, demonstrating unique advantages;
The core bottleneck restricting industrialization is still poor water solubility and low oral bioavailability, while nanotechnology and structural modification (such as 23 hydroxylation) are accelerating the breakthrough.
⚠️ Attention: Pregnant women are prohibited from using it (animal experiments have confirmed its anti early pregnancy effect); The dosage needs to be adjusted when combined with warfarin and hypoglycemic drugs.
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🏭reference
1. Herbal Medicine White Birch Bark Extract Betulinic Acid 98% Powder 472[2025-08-23]
2. Betulinic acid Betulinic acid standard "CAS number: 472 [2020-05-25]
3. Betulinic acid palmate19833-15-9 Price [2022-12-25]
4. Increase the level of C/EBP - β LIP and nitric oxide in tumor to overcome doxorubicin resistance in triple negative breast cancer [225-12-11]
5. Betulinic acid Betulinic acid standard standards_Analytical reference standard
6. Betulinic acid Betulinic acid_inhibitors, antagonists, and agonists
7. Betulinic acid(Lupatic acidBetulic acid)[2022-11-17]
8. High quality 98% Powder Betulinic acid CAS 472-15
9. Betulinic Acid (CAS 472-15-1)[2020-04-30]
10. Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat ...