Vinpocetine Powder CAS 42971-09-5

Is vinpocetine a blood thinner?

Vinpocetine has the function of diluting blood. Vinpocetine has high fat solubility, is easily absorbed by tissues and widely distributed, and can pass through the blood-brain barrier. This indicates that people with bleeding diseases or taking anticoagulants or other drugs for diluting blood should consult their doctors before using Vinpocetine.

What is the function of Vinpocetine?

Vinpocetine powder has many functions, which can improve brain metabolism, blood flow and hemorheology.

1. Neuroprotective effect: Vinpocetine can alleviate the cytotoxicity induced by excitatory amino acids, inhibit voltage-dependent sodium channels and calcium channels, NMDA and AMPA receptors, and enhance the neuroprotective effect of adenosine.

2. Promote brain metabolism: Vinpocetine can increase the intake and consumption of glucose and oxygen in brain tissue, improve the hypoxia tolerance of brain, strengthen the transportation of glucose, the only energy source of brain, through the blood-brain barrier, and transform glucose metabolism into a more favorable aerobic metabolic pathway. Vinpocetine can selectively inhibit calcium-calmodulin-dependent cGMP- phosphodiesterase and increase cGMP and cAMP levels in the brain. Vinpocetine can increase ATP concentration and ATP/AMP ratio; Promote the renewal of norepinephrine and 5- hydroxytryptamine in brain. Vinpocetine also has antioxidant effect.

3. Improve cerebral microcirculation: Vinpocetine can inhibit platelet aggregation, reduce pathological blood viscosity increase, increase erythrocyte deformability and inhibit erythrocyte uptake of adenosine. Vinpocetine can also promote oxygen transport in tissues by reducing oxygen affinity of erythrocytes.

4. Selective increase of cerebral blood flow: Vinpocetine can increase the percentage of cerebral supply of cardiac output and reduce cerebrovascular resistance without affecting the parameters of systemic circulation.

What are the preparation steps of Vinpocetine?

Vinpocetine is prepared by multi-step synthesis using (-)-hydrolicorice extracted from the leaves of Apocynaceae plant Glycyrrhiza uralensis or the seeds of Catharanthus roseus. The total synthesis method uses tryptamine as the raw material and is obtained by the following reaction.

What are the precautions for using vinpocetine?

1. Long-term use should pay attention to check the changes of blood picture.
2. Within the service period, once opened, it should be used as soon as possible.
3. Pregnant women or women who have the possibility of pregnancy are prohibited.
4. Breast-feeding women should use it with caution, and stop breastfeeding when they must use it.
5. Usually, this product has no effect on blood pressure at therapeutic dose, but it may gradually lower blood pressure for sensitive patients.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.