Products Description
Rosiglitazone Powder is a thiazolidinedione anti-diabetic drug. It is an insulin sensitizer that makes cells more sensitive to insulin by binding to PPAR in fat cells. Although rosiglitazone is effective at lowering blood sugar in people with type 2 diabetes, its use has declined dramatically because studies have shown a clear association with an increased risk of heart attack and death.
It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels. Rosiglitazone and pioglitazone are currently thiazolidinedione hypoglycemic drugs commonly used in clinical treatment of diabetes in China. Rosiglitazone is an insulin sensitizer. By increasing the sensitivity of skeletal muscle, liver and adipose tissue to insulin, and improving the utilization of glucose by cells, it can exert the effect of lowering blood glucose, and can significantly reduce fasting blood glucose, insulin and C-peptide levels. It also has a lower effect on postprandial blood sugar and insulin. However, patients are required to have a certain ability to secrete insulin. It is clinically suitable for type 2 diabetes patients who are still not satisfied with diet control and exercise, and can also be combined with biguanides or sulfonylureas to treat patients with poor blood glucose control when used alone.
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COA
| ltems | Standard | Results |
| Appearance | White Powder | Complies |
| Specific rotation | +39.5 to+41.5° | 40.5° |
| State of solution(transmittance) | Clear 98.0% min. | 99.34% |
| Chloridel[cl] | 0.020% max. | 0.01% |
| Ammonium [NH4] | 0.02% max. | 0.07% |
| Sulfate[s04] | 0.020% max | 0.10% |
| lron{Fe] | 10ppm max | 2 ppm |
| Heavy metals |Pb] | 10ppm max | 3ppm |
| Arsenic|As203| | 1ppm max | 0.4ppm |
| Other amino acids | Chromatographically not detectable | Complies |
| Loss on drying | 0.20% max. | 0.10% |
| Residue on ignition[sulfated] | 0.10% max. | 0.02% |
| Assay | 99.0% min | 99.84% |
| Conclusion | Conform with enterprise specification . | |
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Is rosiglitazone still on?
Rosiglitazone Powder is approved for blood sugar control in patients with type 2 diabetes, using glycoglycated hemoglobin A1c (HbA1c) as a substitute endpoint, similar to other hypoglycemic agents. Controversy over side effects has greatly reduced the use of rosiglitazone.
What is the mechanism of action of rosiglitazone?
Mechanism of Action: Rosiglitazone, a member of the thiazolidinedione class of antidiabetic agents, improves glycemic control by improving insulin sensitivity. Rosiglitazone is a highly selective and potent agonist for the peroxisome proliferator-activated receptor-gamma (PPARγ).
Why does rosiglitazone cause weight gain?
It is generally assumed that an increase in adipocyte differentiation is the cause of weight gain in association with TZD treatment which may limit their use. Increased body weight assumed to compromise the positive effects of treatment.
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why choose us
Our Factory
Package
Shipping Methods
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
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