Doxorubicin Hcl Powder CAS 25316-40-9

Doxorubicin HCL powder is also known as adriamycin hydrochloride. Pure doxorubicin (ADM) is an orange freeze-dried powder. It is a chemical semi-synthetic anthracycline antitumor antibiotic. Like daunorubicin and other anthracyclines, doxorubicin can intercalate with cellular DNA and affect DNA synthesis. This product is commonly used in clinical chemotherapy of human cancer, such as hematological malignancy, solid tumor, and soft tissue sarcoma.

What is the pharmacological action of this product?

Doxorubicin HCL powder inhibits DNA superhelix topoisomerase II by embedding and inhibiting the interaction between polymer biosynthesis and DNA. Doxorubicin blocks the closure of the DNA double helix, thereby destroying the replication of the DNA strand. Through embedding, doxorubicin can also act on chromatin with transcriptional activity, resulting in histone changes. The results showed that DNA damage response, epigenome, and transcriptome were not controlled in doxorubicin-treated cells.

What are the negative effects of doxorubicin hydrochloride?

The acute side effects of adriamycin include nausea, vomiting, and arrhythmia. It can also cause neutropenia and complete hair loss. Another mild side effect is discoloration of the urine - which turns bright red 48 hours after administration. When the cumulative dose of adriamycin reaches 500-550mg / m ², Side effects include congestive heart failure (CHF), dilated cardiomyopathy, and even a significantly increased risk of death. Doxorubicin cardiotoxicity is characterized by a dose-dependent decrease caused by mitochondrial oxidative phosphorylation. Reactive oxygen species produced by the interaction between doxorubicin and iron can destroy the myocardium, resulting in the loss of myofibrils and the vacuolation of cytoplasm. In addition, some patients may develop acromegaly (PPE), characterized by skin rashes, swelling, pain, and erythema on the palm or sole of the foot. Because of these side effects and red symptoms, adriamycin has the title of the red devil or red death disease. Chemotherapy can cause hepatitis B, and adriamycin-containing therapy is no exception. Doxorubicin HCL powder and some chemotherapeutic drugs can cause abnormal pigmentation, including cyclophosphamide, antimalarial drugs, amiodarone, heavy metals (except iron), tetracyclines, and antipsychotics.

Clinical application of this product

Doxorubicin hydrochloride is an aperiodic specific anti-tumor drug with a wide anti-tumor spectrum. As a second-line anti-tumor drug, doxorubicin can be used for treatment when the preferred drug is resistant. Doxorubicin is commonly used in the treatment of leukemia and Hodgkin's lymphoma, as well as bladder cancer, breast cancer, gastric cancer, lung cancer, ovarian cancer, thyroid cancer, soft tissue sarcoma, multiple myeloma, etc. For example, the common therapies containing adriamycin are AC (adriamycin, cyclophosphamide), TAC (Keaiyi, CA), ABVD (adriamycin, bleomycin, vincristine, dacarbazine), beaucoup, chop (cyclophosphamide, adriamycin, vincristine, prednisone) and fac (5-fluorouracil, adriamycin, cyclophosphamide). Doxil is mainly used for the treatment of recurrent ovarian cancer after platinum-based chemotherapy, or for AIDS-related Posey's sarcoma.

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Doxorubicin HCL powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: doxorubicin hcl powder cas 25316-40-9, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China