Product Introduction
Atorvastatin powder CAS 134523-00-5 is an HMG-CoA reductase inhibitor in the form of calcium salt. It was first registered in Germany and the UK in February 1997 and first approved for marketing in the UK in April 1997. The relative molecular mass is 1155.36. Atorvastatin is a commonly used statin in clinical practice. In addition to treating hypercholesterolemia, it has a good preventive effect on hypertension, coronary heart disease and cerebrovascular disease.
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| Atorvastatin powder Picture | Atorvastatin powder MF |
Product Application
Atorvastatin powder CAS 134523-00-5 is a statin commonly used in clinical practice. In addition to treating hypercholesterolemia, it has a good preventive effect on hypertension, coronary heart disease and cerebrovascular disease. From the perspective of cardiovascular disease, atorvastatin can protect endothelial function, delay atherosclerosis, protect target organs and improve prognosis in patients with atherosclerosis; atorvastatin can reduce CRP and relieve clinical symptoms in patients with acute coronary syndrome; atorvastatin can reduce CD40 and CD40L expression in patients with hypertension, exert a hypotensive effect and improve the physiological comfort of patients. From the perspective of cerebrovascular disease, atorvastatin can reduce high-sensitivity-CRP levels and improve neurological deficits in patients with acute cerebral infarction; atorvastatin can inhibit the expression of cysteine proteases 3 and 5 and relieve vasospasm symptoms in patients with subarachnoid hemorrhage.
The synthesis of the benzyl ether pyrrole intermediate, as well as the atorvastatin precursor, was performed by the treatment of the corresponding 1,4-diketone intermediates 4 and 10, respectively, with the commercially available primary amine 5 in a pivalic acid-catalyzed Paal-Knorr condensation reaction (Scheme (Scheme1).1). The 1,4-diketone intermediates 4 and 10 were synthesized via a Stetter reaction .
In summary, the α,β-unsaturated ketone 1 was combined with benzaldehydes 2 and 9, respectively, in the presence of triethylamine and the thiazolium bromide catalyst 3 to afford the corresponding 1,4-diketone intermediates 4 and 10, respectively. Atorvastatin was obtained from its precursor after near quantitative removal of the ketal-ester protecting groups in the side-chain with sequential hydrochloric acid and sodium hydroxide treatment.
Product Specification
| Item | Specification | Result | |
| Appearance | White to light yellow powder | Complies | |
| Loss on drying | ≤2.0% | 0.19% | |
| Heavy metals | ≤10 ppm | <10ppm | |
| Water | ≤1.0% | 0.20% | |
| Sulphated ash | ≤0.5%, determined on 1.0 g. | 0.01% | |
| Related substances | Unspecified impurities: for each impurity | ≤0.10% | <0.10% |
| Total Impurity | ≤0.5% | 0.19% | |
| Purity | ≥99.0% | 99.54% | |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.86% | |
| Microbiological Analysis | |||
| Total plate count | ≤1000cfu/g | Complies | |
| Yeast and Moulds | ≤100cfu/g | Complies | |
| E. Coli. | Absent | Negative | |
| Salmonella | Absent | Negative | |
| S.aureus | Absent | Negative | |
| Conclusion | The above items of the product conform to the enterprise Standard | ||
How To Obtain Samples Atorvastatin powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API Atorvastatin powder.
The Best Atorvastatin powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Atorvastatin powder?
Faithfulbio specialize in Atorvastatin powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use Atorvastatin powder for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Atorvastatin powder?
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