Latanoprost powder is a prostaglandin. Prostaglandins are generally characterized by substituents on cyclopentane rings. PGF2α prostaglandins and prostaglandins analogs usually have two hydroxyl groups, which are in cis configuration relative to the cyclopentane ring, and have two side chains in trans configuration, each side chain has a double bond. PGF2α analogs can have different numbers of double bonds in each Chemicalbook side chain and can have different substituents along the side chain. In addition, in some PGF2α analogs, side-chain carboxylic acids can be esterified. It has a saturated side chain PGF2α, in which the carboxylic acid group is esterified. This compound is clinically used to reduce the excessive intraocular pressure of patients with open-angle glaucoma and high intraocular pressure.
Latanoprost powder, a derivative of prostaglandin F2α, is a selective F2α receptor agonist. It is an inactive substance that can quickly penetrate into the cornea and can be hydrolyzed into active free acid in the cornea and plasma. It can increase the outflow of room Chemicalbook water through the cantharidin layer, with a small dosage, but a large amount promoting the filling of room water. The liquid medicine can penetrate into the upper ciliary choroid layer of the eyeball, which has a good effect on lowering intraocular pressure. It can also make glaucoma patients usually blocked.
It is a novel phenyl-substituted propyl ester prostaglandin F2a, which is a selective F2a receptor agonist. It is an inactive substance that can quickly penetrate into the cornea and can be hydrolyzed into active free acid in the cornea and plasma.
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| Real shot pictures of Latanoprost powder | Latanoprost structure diagram |
Product Application
1. Latanoprost powder is suitable for local treatment of open-angle glaucoma and patients with high intraocular pressure which are difficult to treat or tolerate with other drugs.
2. It can increase the outflow of aqueous humor from the eyes through Uveosclera.
3. It can lengthen and thicken eyelashes (like bimatoprost, it is used as an eyelash growth promoter in the cosmetic industry).
4. It can be beneficial to androgenetic alopecia.
Product Specification
Item | Specification | Results |
Assay(on a dried basis) | ≥99.0% | 99.5% |
Appearance | white crystalline powder, odorless | Conforms |
Solubility | Easily soluble in water, insoluble in ethanol | Conforms |
PH | 6.0~7.5 | 6.8 |
Solution clarity and color | the solution should be clear and colorless | Conforms |
Related substances | 5'CMP 0.3% | 0.01% |
Simple impurity | 0.02% | |
Total another impurity | 0.08% | |
Chloride | 0.05% | 0.03% |
Ammonium | 0.05% | 0.02% |
Fe | 0.01% | 0.008% |
Phosphate | 0.1% | 0.06% |
Loss on drying | ≤6.0% | 1.8% |
Heavy metals | 0.002% | Conforms |
Arsenide | 0.0001% | Conforms |
Bacterial Endotoxins | 0.3EU/mg | Conforms |
Microbial Limit | Conforms | Conforms |
Conclusion | The results conform with CP2010 |
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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