9-Me-BC powder is a methylated derivative of β-Carboline, which can be prepared by performing the Eschweier Clark reaction on the free base β-Carboline (Norharman).
Product Specification
| Item | Specification | Results |
| Description | White crystal powder | Confirm |
| Assay | 99.0-101.0% | 98.68% |
| Identification | IR: White crystal powder | Confirm |
| Related compounds | Any impurity ≤0.2% | 0.03% |
| Total impurities≤0.5% | 0.01% | |
| Water | ≤3.0% | 1.58% |
| Loss on drying | ≤3.0% | 1.19% |
| Heavy metal | ≤10ppm | 0.23ppm |
| Conclusion | Conforms with enterprise standards |
What is The Norharman?
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| 2521-07-5 structural formula 9-Methyl-β-carboline | 244-63-3 structural formula β-Carboline |
Norharman, also known as β-Carboline, is a nitrogen-containing heterocyclic organic compound, CAS. NO 244-63-3, molecular formula C11H8N2, and is the structural parent of many alkaloids.Norharmane, also known as Norharman, can be isolated from coffee and is an effective selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μ M.Our company has sufficient supply capacity for Norharman and 9-Me-BC powder, and we can offer you very good bulk prices when you purchase more. If you have plans in this regard, please contact us via email: sales6@faithfulbio.com as soon as possible.
The Eschweiler-Clarke reaction, also known as the Eschweiler-Clark methylation reaction, is a reductive amination reaction. The reaction is named after the German chemist Wilhelm Eschweiler (1860-1936) and the British chemist Hans Thacher Clarke (1887-1972) to commemorate their achievements. The reaction mechanism is that the primary or secondary amine is treated with excess formic acid and formaldehyde to obtain an N-methylated product. The reaction stops when the tertiary amine is produced, and no quaternary ammonium salt is generated. Chiral amines generally do not undergo racemization under the reaction conditions
What is The 9-Methyl-β-carboline?
9-Methyl-β-carboline (9-Me-BC for short) is a known inhibitor of monoamine oxidase A and monoamine oxidase B, and has been proposed for further study in the treatment of Parkinson's disease.
Studies in rodents show that 9-Methyl-β-carboline can inhibit the oxidation of neurotoxin precursor MPTP to dopaminergic neurotoxin MPP+ in vitro. The level of dopamine in hippocampus is increased, and the performance of rodents is greatly improved in spatial learning in radial arm maze test, and the dendritic growth of dentate gyrus of hippocampus is increased.
In the animal model of Parkinson's disease, the number of neurons expressing tyrosine hydroxylase on the left side recovered, while the number of such cells in the striatum decreased by 50% after MPP+ was used.
In the study of primary midbrain dopaminergic neuron cell culture, this substance increased the number of differentiated dopaminergic neurons and produced a higher level of transcription factors related to dopaminergic differentiation.
The in vitro study of dopaminergic neuron cell culture showed that the expression of tyrosine hydroxylase and related transcription factors increased, neurite growth increased, neurons regenerated and the expression of inflammatory cytokines decreased after long-term administration of 9-Me-BC powder.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, so we can not only provide customers with the required 9-Me-BC and Norharman products,Also support the research, production and sales of other heterocyclic compounds.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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