Product Introduction
Methimazole powder is an imidazole antithyroid drug, not a hormone drug. The products on the market are commonly known as methimazole, methimazole, and methithiazole. It is mainly used to treat hyperthyroidism. It inhibits the peroxidase system and hinders the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have shown that it can inhibit the synthesis of antibodies by B lymphocytes, reduce the level of thyroid-stimulating antibodies in the blood circulation, and restore the normal function of suppressive T cells. It is suitable for hyperthyroidism caused by various factors.
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| Methimazole powder Picture | Methimazole powder MF |
Product Application
Methimazole powder is used for the medical treatment of hyperthyroidism. It is suitable for mild cases and those who are not suitable for surgery or radioactive iodine treatment, such as children, adolescents and those who have relapsed after surgery and are not suitable for radioactive iodine treatment. It can also be used as an adjuvant treatment during radioactive iodine treatment.
About the synthesis of methimazole: It is prepared by the reaction of aminoacetaldehyde diethyl acetal with methyl isothiocyanate. It can also be prepared by the reaction of thiocyanic acid with N-substituted aminoacetal. It can also be prepared by the reaction of thiocyanic acid with N-substituted aminoacetal. Base hydrolysis of imidazole carboxylate was observed to be an efficient route for the scalable synthesis of the antithyroid drug methimazole.
Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate was produced as a key intermediate in the reaction of 1-methyl-1H-imidazole with ethyl chloroformate and sulfur. Compound 12 undergoes hydrolysis in two steps in the presence of a base to give methimazole with an overall yield of 78%. The process was studied through the Quality by Design (QbD) concept and observed to be robust.
Product Specification
| Items | Standards | Results |
| Physical Analysis | ||
| Description | White to slightly cream or light yellow crystalline powder | Complies |
| Assay | Synephrine hcl 98% (HPLC) | 98.12% |
| Mesh Size | 100 % pass 80 mesh | Complies |
| Ash | ≤ 5.0% | 3.85% |
| Loss on Drying | ≤ 5.0% | 3.45% |
| Chemical Analysis | ||
| Heavy Metal | ≤ 10.0 mg/kg | Complies |
| Pb | ≤ 2.0 mg/kg | Complies |
| As | ≤ 1.0 mg/kg | Complies |
| Hg | ≤ 1.0 mg/kg | Complies |
| Microbiological Analysis | ||
| Residue of Pesticide | Negative | Negative |
| Total Plate Count | ≤ 1000cfu/g | Complies |
| Yeast&Mold | ≤ 100cfu/g | Complies |
| E.coil | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion | Conform with the enterprise standard | |
How To Obtain Samples Methimazole powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API Methimazole powder.
The Best Methimazole powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Methimazole powder?
Faithfulbio specialize in Methimazole powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use Methimazole powder for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Methimazole powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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