Nateglinide Powder CAS 105816-04-4

Nateglinide, Mitiglinide, and Repaglinide are three commonly used non sulfonylurea insulin secretagogue hypoglycemic products, which were first developed by Ajomoto Corporation in Japan. And the powder of nateglinide powder is off white in color; Its chemical structure belongs to formylmethylbenzoic acid (CMBA), which is a derivative of D-phenylalanine. It is a new generation of amino acid derivatives that promote insulin secretion And it is currently the only non sulfonylurea insulin secretagogue with an amino acid structure.

What is the difference between Repaglinide and Nateglinide?

Repaglinide is a novel short acting insulin secretion lowering product that acts on pancreatic B cells to promote insulin secretion and rapidly reduce blood glucose levels. Therefore, Repaglinide relies on functional beta cells in the pancreas. The insulin secretion promoting effect of nateglinide depends on blood glucose levels, and the insulin secretion promoting effect is weakened when glucose levels are low. Nateglinide has the characteristics of rapid onset and disappearance of effects on B cells. From the perspective of clinical manifestations, repaglinide was absorbed rapidly, and the onset time was 0-30 minutes. The plasma drug concentration of diabetes patients reached the peak within 1 hour after taking the drug, then decreased rapidly, and was cleared within 4-6 hours. The half-life of plasma is about 1 hour. It can be used for type 2 diabetes patients who can not control blood sugar effectively after diet control. It can also be used in combination with metformin, and the combination of the two has a synergistic effect on controlling blood sugar. It has the same curative effect for obese and non obese type 2 diabetes patients. Nateglinide can be used in patients with type 2 diabetes who cannot effectively control their blood sugar after diet control. Clinical trials have shown that nateglinide can be used in combination with complementary metformin or glitazone drugs to improve blood glucose control. The maximum blood drug concentration is 1-2 hours, and the duration of action is 4-6 hours.
To sum up: In addition to their different mechanisms of action, repaglinide and nateglinide are very effective in coping with type 2 diabetes in which diet control, weight loss and exercise cannot effectively control their hyperglycemia, and both can be used in combination with metformin when metformin alone is not ideal.Our company is committed to developing more hypoglycemic products, such as Nateglinide, Mitiglinide, acarbose, and Repaglinide. If you have any needs or interests in this area, please leave us a message via email:sales6@faithfulbio.com

Is the use of Nateglinide tablets before or after meals?

The main mechanism of action of nateglinide is to inhibit the early response of pancreatic beta cells to release insulin and increase the quantity and activity of insulin secretion by pancreatic beta cells, thereby reducing blood glucose levels. Although there are no strict regulations on the timing of taking nateglinide tablets. However, clinical studies have found that taking nateglinide tablets before meals can help with rapid drug absorption, and within one hour of taking the medication, most can reach the average peak concentration of the drug, thereby helping to lower blood sugar levels during meals. If taken after meals, it may not be easily absorbed by the body due to the influence of food. So to avoid a weakened effect and poor blood sugar suppression, doctors usually recommend taking it within 15 minutes before each meal.
For most adults without gastrointestinal diseases or other complications, it is recommended to take it once a day, preferably on an empty stomach in the morning or within 30 minutes before or after breakfast. Because at this time, the impact of food on drug absorption is relatively small, which can better exert the effect of drugs. Older patients can set a reminder alarm in advance to avoid forgetfulness, so as not to take medication at the wrong time and prevent the patient's condition from worsening.
If, for some patients with gastrointestinal diseases such as chronic gastritis and peptic ulcers, taking it before meals may stimulate the gastric mucosa and cause discomfort, they can choose to take it after meals under the guidance of a doctor to alleviate discomfort. In addition, if severe symptoms such as nausea, vomiting, diarrhea, etc. occur, the doctor should be informed promptly and medication should be stopped.
In short, the specific medication time depends on the individual's physical condition and the doctor's advice. Before starting to take any new medication, please consult a professional doctor's opinion to ensure safe and effective use.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Our company is committed to developing more hypoglycemic products, such as Nateglinide, Mitiglinide, acarbose, Metformin and Repaglinide. If you have any needs or interests in this area, please contact us

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