What is Kanamycin sulfate?
Kanamycin Sulfate is an effective antibacterial agent, which can inhibit translocation and lead to coding errors by binding to 70 S ribosome subunit. Kanamycin sulfate has good inhibitory activity on both M. tuberculosis (sensitive or drug-resistant) and K. pneumonia, and can be used for the study of tuberculosis and pneumonia.
Kanamycin Sulfate powder is a white crystalline powder, odorless, hygroscopic and soluble in water and organic solvents. It has strong antibacterial activity, especially for respiratory tract infection pathogens such as Gram-positive bacteria and pneumococcus. Kanamycin Sulfate is stable under acidic conditions, but easy to decompose under alkaline conditions.
| Product name | Kanamycin sulfate |
| CAS | 25389-94-0 |
| Molecular formula | C18H38N4O15S |
| Molecular weight | 582.58 |
| EINECS Number | 246-933-9 |
| Storage condition | 2-8°C |
| Melting point | 250°C |
| Solubility | H2O: 10-50 mg/mL as the stock solution. The stock solution should be stored at 2-8 C. Stable at 37°C for 5 days. |
| Appearance | White to off-white powder |
| Density | 1.3619 (rough estimate) |
| Water solubility | Soluble in water at 10mg/ml |
What is the pharmacological action of Kanamycin sulfate?
1. Antibacterial effect: Kanamycin sulfate has strong antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria, especially the common Gram-negative bacilli in ophthalmology.
2. protein synthesis inhibition: Kanamycin sulfate can bind to the 30S ribosome subunit of bacteria and block the synthesis of protein.
3. Changes in cell membrane permeability: Kanamycin sulfate changes the permeability of bacterial cell membrane, leading to the leakage of internal substances of bacterial cells, thus playing a bactericidal role.
Product Specification
| Item | Specification | Results |
| Characters | White or almost white crystalline powder | Confirms |
| Assay (HPLC) | 99.0~101.0% | 99.82% |
| Specific Rotation | +116°~+123° | Confirms |
| Loss on drying | Not more than 3.0% | Confirms |
| PH | 7.0~9.0 | 8.0 |
| Flashing Point | 524.2°C | Confirms |
| Boiling Point | 943.2°C at 760 mmHg | Confirms |
| Melting point | 250.0°C | Confirms |
| Conclusion | Conform USP Standard. | |
What can Kanamycin Sulfate be used for?
1. Kanamycin sulfate powder is a broad-spectrum antibiotic, which is mainly used to treat bacterial infections.
2. Kanamycin sulfate is an aminoglycoside antibiotic. It inhibits the synthesis of protein by binding to the 30S subunit of bacterial ribosome.
3. It can also be used for preventive application before or during operation to prevent infection.
4. It can be used as veterinary medicine to treat or prevent farm animals' infectious diseases.
5. Kanamycin sulfate is a broad-spectrum antibiotic, which has antibacterial effect on both gram-positive and gram-negative bacteria.
6. It can be used in biochemical research.
7. Application of biotechnology to inhibit the synthesis of protein. The kanamycin B(neoR, KanR phenotype) resistance gene was used as a selection agent for transforming cells.
HTML5 atlas of Kanamycin sulfate
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What is the compatibility effect of Kanamycin Sulfate with?
Kanamycin Sulfate is a commonly used aminoglycoside antibiotic, which belongs to bacteriostatic preparation. The compatibility between Kanamycin Sulfate and what is effective needs to be decided by doctors according to different situations.
1. Anticholinergic drugs: Kanamycin Sulfate has bacteriostatic effect, which mainly binds to the 30s subunit of bacterial ribosome, and can inhibit the synthesis of bacterial protein, but this bacteriostatic effect is very weak.
2. Anti-tuberculosis drugs: Kanamycin Sulfate also has anti-tuberculosis effect, but it is easy to cause drug resistance of tuberculosis when used alone.
However, it should be noted that Kanamycin Sulfate powder can cause severe ototoxicity and nephrotoxicity. For example, it can increase ototoxicity, nephrotoxicity and neuromuscular block if it is used in combination with other aminoglycosides or locally or systemically. Therefore, special attention should be paid when using this product.
What are the side effects of Kanamycin Sulfate?
1.Kanamycin Sulfate has great side effects, and the key side effect is the eighth cranial nerve.
2. The toxic and side effects of renal function can often cause slight proteinuria, tubular urine and a small number of blood cells and white blood cells in urine, and occasionally cause blood urea nitrogen to rise.
3. The main manifestation of neurotoxicity is muscle nerve block, which can cause inhalation numbness, numbness and abnormal visual effects.
4. Allergic symptoms, such as macula, drug fever, itchy skin, increased eosinophils, etc.
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