Azilsartan powder is an AT1 subtype angiotensin II receptor antagonist (ARB) developed by Takeda Corporation in Japan. It is commonly used in the treatment of hypertension and is currently the only angiotensin II receptor antagonist (sartan) product in end-stage clinical practice. Its precursor product is Azilsartan Medoxomil Potassium. According to relevant clinical trial data, this product has significant advantages in reducing blood pressure compared to other products. The effect comparison is shown in the table below:
| Item 1 (experimental subjects: 1291 people, experimental time: 42 days) | ||
| Azilsartan Medoxomil | 40 mg | 13.4mmHg |
| Azilsartan Medoxomil | 80 mg | 14.5mmHg |
| Olmesartan Medoxomil | 40 mg | 12.0mmHg |
| Valsartan | 320mg | 10.2mmHg |
| Item 2 (experimental subjects: 1272 people, experimental time: 42 days) | ||
| Azilsartan Medoxomil | 20 mg | 10.8mmHg |
| Azilsartan Medoxomil | 40 mg | 12.1mmHg |
| Azilsartan Medoxomil | 80 mg | 13.2mmHg |
| Olmesartan medoxomil | 40 mg | 11.2mmHg |
What are the details of the use of Azilsartan?
We already know that azilsartan belongs to the category of angiotensin II receptor antagonists. Has a strong and long-lasting effect on lowering blood pressure. In addition to reducing blood pressure function, it also has the effect of improving ventricular remodeling and improving prognosis, which can be used to treat cardiovascular diseases such as coronary atherosclerosis. But the main function of this product is still to lower blood pressure.
Azilsartan tablets can not only be used alone to lower blood pressure in clinical practice, but are often used in combination with various other antihypertensive products, especially for patients with grade 3 and above hypertension. The use of Azilsartan powder alone may not be able to control blood pressure. In this case, combination therapy with calcium antagonists, beta blockers, or diuretics can be considered. Thus, it can inhibit the production of aldosterone, improve the retention of water and sodium in the body, and achieve the effect of combined hypotension.However, it should be noted that whether used alone or in combination, it is necessary to monitor the side effects of all products during use.,Our company can provide various antihypertensive raw materials, such as Azilsartan, Olmesartan, Valsartan, Olmesartan, etc. If you have research needs or processing and production plans in this area, please contact us via email:sales6@faithfulbio.com
Product Specification
| Item | Specification | Results |
| Description | White crystal powder | Confirm |
| Assay | 99.0-101.0% | 99.88% |
| Identification | IR: White crystal powder | Confirm |
| Related compounds | Any impurity ≤0.2% | 0.49% |
| Total impurities≤0.5% | 0.88% | |
| Water | ≤3.0% | 0.25% |
| Loss on drying | ≤0.5% | 0.19% |
| Heavy metal | ≤10ppm | 0.23ppm |
| Conclusion | Conforms with enterprise standards |
Regarding the side effects of azilsartan,Why do we need to take blood pressure regularly?
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The common side effects of azilsartan include hyperkalemia, elevated creatinine, and allergic reactions. Excessive use of this medication may lead to hypotension. Before use, patients who are allergic to azilsartan , those with significantly elevated creatinine levels exceeding 3mg/dL, bilateral renal artery stenosis, and hyperkalemia are among the diseases Not recommended, let alone allowed to be used.After using azilsartan, some patients may experience gastrointestinal discomfort such as diarrhea and bloating, while a small number of patients may experience vascular and neurological edema, such as swelling of the face, lips, and tongue. Severe and rare cases may include shock, hypotension, and syncope. So it is necessary to test blood pressure, and if you feel any abnormal fluctuations in your blood pressure and discomfort such as dizziness, chest tightness, etc., please stop using this product and seek medical attention as soon as possible. |
| Molecular formula of azilsartan | When in use,Pay attention to monitoring your blood pressure and related side effects. |
Measartan(Azilsartan Medoxomil) VS alisartan
1. Comparison of antihypertensive effects
In terms of blood pressure lowering effect, compared with Allisartan, Azilsartan Medoxomil still has certain advantages. But, they all belong to "prodrugs", which means they do not have product activity themselves and can only become products with antihypertensive activity after entering the human body and undergoing metabolism.After Allisartan is converted into losartan in vivo, it can only be used.However, Azilsartan Medoxomil can only play a role in lowering blood pressure by converting it into azilsartan.
Losartan is a classic antihypertensive product of the older generation, but its antihypertensive effect is relatively weak, Azilsartan(Metabolic active substances of Azilsartan Medoxomil), on the other hand, has stronger and more stable binding force with ARB receptor and higher bioavailability.
The clinical trial results showed that after 8 weeks of antihypertensive product treatment with 80mg of Azilsartan Medoxomil, the effect of reducing systolic blood pressure was stronger compared to the dose of 320mg of valsartan.
From the perspective of clinical application, there are also many patients who do not meet the blood pressure control standards after taking other sartan products. After switching to Azilsartan Medoxomil, their blood pressure is further reduced and controlled. Therefore, in terms of blood pressure lowering effect, Azilsartan Medoxomil potassium still has advantages over valsartan.
2.Safety comparison
In terms of product safety, the clinical safety of alisartan ester is relatively good in terms of the incidence of adverse reactions, and the incidence of adverse reactions is similar to that of losartan. Most of the adverse reactions are mild and short-lived, which are generally tolerable. The main adverse reactions that should be paid attention to include elevated blood potassium and angioneurotic edema. The clinical adverse reactions of Azilsartan Medoxomil potassium are mild to moderate, the most common adverse reaction is dizziness, and the incidence of adverse reactions of 40mg and 80mg is similar, with no significant difference.
In the aspect of medication for special population, Azilsartan Medoxomil has undergone liver metabolism, so it is recommended to closely monitor the patients with mild to moderate liver injury, and consider choosing 20mg as the initial dose. It is not recommended to use this product for patients with severe liver failure.
At present, the dose adjustment information of Allisartan for patients with liver failure has not been established, while for patients with renal failure, Azilsartan Medoxomil does not need to adjust the dose for patients with mild to moderate liver failure, and it is not recommended to use this product for patients with severe renal failure and end-stage renal disease. Dose adjustment and safety information of Allisartan are also not established, but it is also not recommended for patients with severe renal insufficiency.
3.Have different effects on uric acid
If the biggest difference between the two Pharmaceutical raw materials is the difference in the strength of antihypertensive effect, another difference is the influence on uric acid metabolism.Allisartan ester is metabolized into Losartan carboxylic acid in the body, which can play a certain role in lowering blood pressure and uric acid, which is more friendly to patients with high uric acid; However, Measartan may lead to the increase of uric acid. Patients with gout with high uric acid should pay attention to the monitoring and control of uric acid if they choose Measartan.
How should different hypertensive patients choose?
First of all, for patients with mild to moderate hypertension, they are all optional products, which can be used alone or combined with other products to reduce blood pressure synergistically; For patients with severe hypertension, it is suggested to consider Azilsartan powder, which is more effective, to improve the antihypertensive effect.
For patients with hyperuricemia, Allisartan Isoproxil should be preferred. It can reduce hyperuricemia to a certain extent, and will not affect the uric acid level of patients with hyperuricemia. It is a more suitable antihypertensive select to take, but Mesartan potassium (Azilsartan) is not unavailable, which generally causes a small increase in uric acid, and the incidence rate is not high. It is completely possible to monitor and use it safely.
From the point of product interaction, Allisartan is not metabolized by the liver, and the product interaction is relatively less. When it is used in combination with other products, the safety is higher. However, it should be noted that diet will affect the absorption of Allisartan, so it is generally recommended to take this product on an empty stomach. Azilsartan has a stronger antihypertensive effect, and the food does not affect its absorption, so the timing of taking it is more flexible.
In a word, for these two new types of antihypertensive API powder, it can be said that they have their own characteristics and advantages and disadvantages, so friends can choose and use them reasonably according to their own actual situation.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, so we can not only provide customers with the required Azilsartan and alisartan and Olmesartan and Valsartan, but also support the development and provision of new products.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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