Streptomycin Sulphate Powder CAS 3810-74-0

Streptomycin sulfate is the sulfate form of streptomycin, which is an antibiotic produced by Streptomyces griseus in soil. Pure Streptomycin Sulphate powder is white or white-like powder, odorless, slightly bitter in taste and hygroscopic.
Streptomycin solution is a high-quality bactericide. Pure powder is soluble in water and its properties are stable (at room temperature, the PH value can be controlled at 3 ~ 7 for 2 ~ 4 weeks), and the pure powder is particularly stable in dry state. After calculation, the titer remains unchanged after being stored in a closed place in the dark for more than 4 years. However, if you encounter acid, alkali and oxidant, it is easy to destroy and fail. Insoluble in ethanol or chloroform.

What is the difference between penicillin and streptomycin?

1. Mechanism of action
Penicillin mainly inhibits the synthesis of mucin in bacterial cell wall, which leads to the defect of bacterial cell wall, makes bacteria lose the protection of cell wall and leads to bacterial death. Streptomycin inhibits the synthesis of protein mainly by binding to the 50S subunit of bacterial ribosomes.

2, antibacterial spectrum
Penicillin mainly has antibacterial effect on Gram-positive cocci, such as Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Streptomycin has antibacterial effect on pathogens such as Gram-negative Bacillus, Mycobacterium tuberculosis, Mycoplasma and Chlamydia.

3, antibacterial activity
The antibacterial activity of penicillin is higher than that of streptomycin, while that of streptomycin is weaker than that of penicillin.

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What are the pharmacological effects of streptomycin sulfate?

Streptomycin Sulphate powder is an aminoglycoside drug. Its mechanism of action is to act on ribosomes in bacteria, inhibit bacterial protein synthesis, and destroy the integrity of bacterial cell membrane. Specifically, it is as follows:
After streptomycin sulfate enters the body tissue, it passively diffuses through the outer membrane pore protein, and then enters the cell through the cell membrane through this transport system, combining with the special receptor protein of the 30s subunit of the ribosome of pathogenic microorganisms, interfering with the formation of the initial complex between messenger RNA and the 30s subunit, causing DNA errors, or making the paired amino acids subject to competitive confrontation, leading to the synthesis of nonfunctional protein, splitting the ribosome of pathogenic microorganisms, and finally destroying the synthetic protein, resulting in the death of pathogenic microorganisms.

What is the strong antibacterial effect of streptomycin on mycobacterium tuberculosis?

We know that this product is the preferred drug for treating Mycobacterium tuberculosis, with strong antibacterial effects at low concentrations (usually 0.5mg/L) and bactericidal effects at high concentrations. Since only 10% can penetrate into somatic cells, it is ineffective against intracellular tuberculosis bacteria and can only kill extracellular tuberculosis bacteria. It has a stronger bactericidal effect on bacteria in the reproductive period than on bacteria in the resting period. Although streptomycin can easily bind to the 30S subunit of bacterial ribosomes, inhibiting bacterial protein synthesis, bacteria are also prone to developing drug resistance upon contact with streptomycin. However, the combination of streptomycin and other antibiotics or anti tuberculosis drugs can reduce or delay the development of drug resistance.
Unlike penicillin, its bactericidal rate is directly proportional to the drug concentration, and its antibacterial effect is strongest at pH 7.8, which greatly weakens when the pH drops below 6.

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