Halofuginone Powder CAS 55837-20-2

Changshan ketone is a relatively new broad-spectrum anti coccidian drug, which has the advantages of small dosage and no cross resistance with other anti coccidian drugs. Halofuginone powder is an alkaloid extracted from the Chinese herbal medicine Dichroa febrifuga Lour. and chemically synthesized. Therefore, this product not only has high activity in killing coccidiosis, but also does not easily develop drug resistance after long-term use, and there is no problem of chemical pesticide residue.

Our company can provide a variety of veterinary drugs, such as Halofuginone, Nicarbazin, praziquantel, mebendazole, levamisoleetc. Low price. If you are interested, please leave me a message via email:sales6@faithfulbio.com

How to use Halofuginone?

Halofuginone hydrobromide, as a feed additive, is widely used to prevent and control coccidiosis in poultry, and the chemical structure of this product is unique and there is no cross-resistance with other existing anticoccidial drugs.
Clinical application shows that it has obvious inhibitory and killing effects on three stages of coccidia development cycle, namely sporozoites, first generation schizonts and second generation schizonts; It is also effective for most gram-positive bacteria. It can not only control the clinical symptoms of coccidiosis, but also completely inhibit the expulsion of oocysts (except Eimeria maxima), so that the environment is no longer polluted and the possibility of reinfection is reduced. However, it cannot be said that the use of pure halofuginone powder is unrestrained. On the contrary, if it is used improperly, non-toxic products will become toxic and harmful products.
1. The safety range of halofuginone is narrow. The therapeutic concentration (3mg/kg) is safe for chickens, turkeys and rabbits, but it may inhibit the growth rate of waterfowl (geese and ducks).
2. If it is used continuously and unrestrained, it will not only lead to serious coccidia drug resistance, but also inhibit the synthesis of type I collagen cells, which will lead to skin tearing, so it is necessary to grasp the withdrawal period.
3. The treatment concentration can affect the weight gain rate of chickens. There is evidence that the feed concentration of 6mg/kg will seriously reduce the food intake of sick chickens, and most chickens will no longer eat at the feed concentration of 9mg/kg. And too high concentration will accelerate the blood coagulation of turkey and affect the immunity of poultry to coccidia. Therefore, the ingredients must be thoroughly mixed. Generally, the uniformity is required to be between 2.1 and 3.9 mg/kg.
4. Because fish and aquatic organisms are extremely sensitive to this product, this product should be kept away from water sources, and turkeys over 12 weeks old, difficult chickens over 8 weeks old, laying hens and waterfowl are prohibited.
5. This product is usually mixed with feed once a day for 3 days, and cannot be mixed with other similar products.
6. To strictly abide by the withdrawal period, the conventional withdrawal period for poultry is 4 days, and if it is a broiler, it is extended to 5 days; Turkey extended to 7 days.

What is the mechanism of action of Halofuginone?

Halofuginone inhibits the invasion of Eimeria tenella spores and the division of merozoites, and interferes with the protein synthesis of parasites. Prevent its development and reproduction, so as to achieve the effect of killing coccidia.

1. Inhibiting the invasion of spores of the soft and tender Amy's ear ball worm: Halofuginone powder can reduce the ability of the egg sac to remove the spore sac, thereby reducing its ability to infect cells and preventing its invasion of host cells.

2. Inhibition of schizogenesis: Halofuginone raw material inhibits the division of schizonts into merozoites, causing them to vacuolize and ultimately disrupting their development, resulting in the inhibition of schizonts and merozoite development, slowing down their development rate, and ultimately being cleared by the body's immune system.

3. Interference with protein synthesis: Recent studies have shown that Changshanketone is an efficient inhibitor of parasitic protein synthesis enzymes, which can cover all three binding sites (tRNA, L-Pro, ATP) on PRS, thereby hindering parasite protein synthesis and causing sporozoites, schizonts, and merozoites of nematodes to vacuolize and fail to grow and reproduce.

Halofuginone is also used in antimalarial treatment.

Changshan, a traditional Chinese medicine, contains active ingredients such as dichroine, which can interfere with the protein synthesis process of plasmodium, thus killing plasmodium in the blood of infected people. Although the antimalarial effect of halofuginone is equivalent to that of artemisinin, its mechanism of action is not completely clear, and the mitigation of toxic and side effects needs further study.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide a variety of veterinary drugs, such as Halofuginone, Nicarbazin, praziquantel, mebendazole, levamisole and so on. at a low price. If you need it, please leave a message

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