Promethazine HCL Powder CAS 58-33-3

Promethazine hydrochloride is an organic compound with the chemical formula C17H20ClN2S. It is an antihistamine that can competitively block the histamine H1 receptor, counteract histamine induced capillary dilation, and reduce its permeability. Therefore, it can alleviate coughing caused by stimulation of the trachea. Pure Promethazine HCL powder is a white or off white powder or granule, almost odorless, and deteriorates over time in the air, appearing blue. This product is highly soluble in water, soluble in ethanol or chloroform, and almost insoluble in acetone or ether.

What are the pharmacological effects of promethazine hydrochloride?

Promethazine HCL powder is a derivative of phenothiazine and belongs to the class of antihistamines. It can be used for antiemetic, anti dizziness, motion sickness, and sedative hypnotic purposes.
1. Antihistamine effect: Competes with histamine released by tissues for H1 receptors, can antagonize histamine's contraction or constriction of smooth muscles in the gastrointestinal tract, trachea, bronchi, or bronchioles, and can relieve histamine's spasmodic and congested effects on bronchial smooth muscles.
2. Antiemetic effect: It may be related to the inhibition of the emetic chemoreceptors in the medulla oblongata.
3. Anti motion sickness effect: It may act on the vestibular and vomiting centers as well as the midbrain sensory receptors through central anticholinergic properties, mainly blocking the excitation of cholinergic synaptic labyrinth impulses in the vestibular nucleus area.
4. Sedative and hypnotic effects: The mechanism of inhibiting the central nervous system is not yet fully understood, possibly due to indirectly reducing the stress response of the brainstem reticular formation activation system.

What is the clinical use of promethazine?

As mentioned above, promethazine hydrochloride can block H1 receptors in smooth muscle, capillary wall and other tissues, thus playing a competitive antagonistic role with histamine, and it has a significant central stabilizing effect when used alone. If combined with other anesthetic, hypnotic and analgesic products, it can play a role in strengthening the efficacy. In addition, this product can not only suppress vomiting, but also lower body temperature. In addition, it can also be used for food allergy, urticaria, skin scratches, allergic conjunctivitis, seasonal allergic rhinitis and so on.Although this product has low price, clear function and is widely accepted by the public, its side effects can not be ignored. Especially patients with pyloric obstruction, prostatic hypertrophy, bladder neck obstruction, angle-closure glaucoma, hyperthyroidism and hypertension need to use this product with caution. If normal people use it, they should also avoid driving vehicles, manipulating machines or engaging in aerial work during medication.

Should we pay attention to the common side effects of thiazides?

Promethazine HCL powder is a phenothiazine derivative, which has no obvious side effects in small doses, but it may also cause symptoms such as drowsiness and dry mouth. If the dosage is too large and used for a long time, patients may also have common side effects such as abdominal pain, diarrhea, dizziness and convulsion.
1. If you use too much, you may be clumsy or eccentric. In severe cases, you may feel sleepy or flushed, have fever, be short of breath or have difficulty breathing, increase your heart rate (antimuscarinic (M) receptor effect), and have muscle spasms, especially in the muscles of the neck and back.
2. If you use it for a long time, it will increase the skin's sensitivity to light, with nightmares, excitability, excitability, hallucination and toxic delirium.
3. If the following conditions persist, we should pay attention to them: drowsiness is more common; Less common are blurred vision or color blindness (mild), dizziness, dry mouth and nasopharynx, tinnitus, rash, stomach pain or discomfort, unresponsiveness (more common in children), nausea or vomiting [even jaundice when surgery and/or other drugs are used. A burning or stinging sensation in the rectum may occur when suppositories are used.
4. If there is restless sitting, walking hard, spasmodic twitching of head and face muscles or tremors of hands, it may be an extrapyramidal reaction. Such symptoms are more common in children. At this time, you should immediately stop taking drugs and seek medical treatment.
5. This product may cause abnormal blood pressure, leukopenia, granulocytopenia, or aplastic anemia, but this is a rare situation.

Therefore, we should use this medicine under the guidance of a doctor to avoid improper use and harm to health. And infants under 3 months should not use this product.

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