What is Ampicillin?
Ampicillin is a broad-spectrum β -lactam antibiotic, which can resist a variety of gram-positive and gram-negative bacteria.
Ampicillin is a semi-synthetic broad-spectrum penicillin antibiotic. Its free acid contains 3 molecules of crystal water.
Ampicillin powder is white or white-like powder or crystal. Odorless, slightly bitter, soluble in water, slightly soluble in ethanol, insoluble in ether, insoluble in chloroform, ethanol, ether or volatile oil. Not resistant to enzyme, stable to acid. Soluble in dilute acid solution or dilute alkali solution, but unstable in water and strong acid-base solution. Therefore, the stability and product dissolution of veterinary oral preparations determine one of the key technical indicators for its efficacy.
| Product name | Ampicillin |
| CAS | 7177-48-2 |
| Molecular formula | C16H25N3O7S |
| Molecular weight | 403.45 |
| EINECS Number | 615-347-9 |
| Storage condition | Sealed in dry,2-8°C |
| Melting point | 208 °C (dec.)(lit.) |
| Solubility | Soluble in NH4OH1M, the solubility is 50mg/mL, clear and colorless. |
| Appearance | White to off-white powder |
| Boiling point | 684℃ |
| Water solubility | 0.1-1 g/100 mL at 21 ºC |
What is the pharmacological action of Ampicillin?
Ampicillin's antibacterial mechanism is mainly to inhibit and prevent the synthesis of bacterial cell wall by acting on bacterial cell wall, so it can not only inhibit its proliferation, but also directly kill various sensitive bacteria. Its effect on sensitive bacteria in each reproductive stage.
Its effect on gram-positive bacteria is similar to that of penicillin, especially on Streptococcus viridans and Enterococcus, but its effect on other gram-positive bacteria is poor, especially on penicillin-resistant Staphylococcus aureus.
In the spectrum of gram-negative bacteria, it is sensitive to Ampicillin, such as Escherichia coli, typhoid and paratyphoid bacilli, dysentery bacilli, Proteus mirabilis and influenza bacilli, but it is easy to produce drug resistance.
Product Specification
| Item | Specification | Results |
| Physical Analysis | ||
| Description | White Powder | Complies |
| Assay | 99% | 99.60% |
| Mesh Size | 100 % pass 80 mesh | Complies |
| Ash | ≤ 5.0% | 2.85% |
| Loss on Drying | ≤ 5.0% | 2.65% |
| Chemical Analysis | ||
| Heavy Metal | ≤ 10.0 mg/kg | Complies |
| Pb | ≤ 2.0 mg/kg | Complies |
| As | ≤ 1.0 mg/kg | Complies |
| Hg | ≤ 0.1mg/kg | Complies |
| Microbiological Analysis | ||
| Residue of Pesticide | Negative | Negative |
| Total Plate Count | ≤ 1000cfu/g | Complies |
| Yeast&Mold | ≤ 100cfu/g | Complies |
| E.coil | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion | Conform USP Standard. | |
How does Ampicillin work?
Ampicillin powder is a bactericidal antibiotic. It can permeate gram-positive bacteria and some gram-negative bacteria. Pbps, which binds to the bacterial cell wall, blocks the third and final stage of bacterial cell wall synthesis, and eventually leads to cell lysis.
HTML5 atlas of Ampicillin
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Where is Ampicillin used?
1. Ampicillin powder is used as an antibiotic.
2. It is used to treat sensitive enterococci, dysentery bacilli, typhoid bacilli, Escherichia coli, Listeria, aerogenes, influenza bacilli and Proteus mirabilis.
3. It is a β -lactam antibiotic, and its amino group is linked to the result of penicillin. Relying on the inner surface of bacterial cell membrane inactivates transpeptidase and inhibits the synthesis of bacterial cell wall.
IR1 of Ampicillin
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What products will interact with Ampicillin?
1. The combination of Ampicillin Powder and Probenecid can prolong the half-life of Ampicillin.
2. Ampicillin and kanamycin have synergistic antibacterial effect on Escherichia coli and Proteus.
3. Ampicillin should be used alone, but not simultaneously with clindamycin phosphate, lincomycin hydrochloride, polymyxin B, erythromycin, m-hydroxylamine, dopamine, atropine, calcium gluconate, vitamin B group and vitamin C.
4. Ampicillin can accelerate the metabolism of estrogen or reduce its enterohepatic circulation, thus reducing the effect of contraceptives.
Is Ampicillin the same as amoxicillin?
Ampicillin and amoxicillin are antibiotics, and there are similarities and differences between them. Ampicillin powder belongs to β -lactam antibiotics, and its molecule contains penicilline, which can destroy the cell wall of bacteria and play a bactericidal role in the reproductive period of bacterial cells. It is extracted from Penicillium. Amoxicillin is a semi-synthetic penicillin broad-spectrum β-lactam, which has stronger bactericidal effect than penicillin, stronger ability to penetrate cell membrane, and acid resistance, and its absorption rate in gastrointestinal tract will increase.
What are the differences between Ampicillin and penicillin?
Ampicillin and penicillin belong to penicillin antibiotics, and their therapeutic effects are basically the same, but there are still some differences in their chemical structures. Ampicillin is semi-synthetic, and penicillin can be divided into natural penicillin and synthetic penicillin. It can be used for most gastrointestinal inflammation and respiratory inflammation. Generally speaking, the effect is good. For the selection of antibiotics, it is better to choose low-grade antibiotics first to avoid drug resistance after long-term use.
How and where to buy Ampicillin Powder wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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