Product Introduction
Celecoxib powder is a new generation of non-steroidal anti-inflammatory analgesics. It inhibits the production of prostaglandins by selectively inhibiting cyclooxygenase-2 (COX-2), achieving anti-inflammatory and analgesic effects. The phenyl group of celecoxib binds to the hydrophobic channel of COX-2, and the hydrophilic sulfonamide group forms a hydrogen chain with the arginine at position 513 and the histidine at position 90 in the "side pocket" of COX-2. This product also closely binds to the arginine at position 120 of COX-2, thereby inhibiting X-2 from converting arachidonic acid into prostaglandins that are harmful to the human body. Due to the subtle differences in the structures of COX-1 and COX-2, this drug cannot enter the COX-1 molecule, nor can it inhibit the conversion of arachidonic acid into prostaglandins by COX-1.
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| Celecoxib powder Picture | Celecoxib powder MF |
Product Application
Celecoxib powder has good anti-inflammatory and analgesic effects, protects gastric mucosa, maintains renal blood flow, and regulates platelet aggregation, and solves the digestive tract irritation of commonly used NSAIDs. It is used to treat arthritis and has anti-inflammatory and analgesic effects, and relieves the symptoms and signs of osteoarthritis and rheumatoid arthritis.
The objective of this study was the identification of celecoxib through several analytical methods. Celecoxib was identified by its melting range, ultraviolet and infrared spectrophotometry, thin layer chromatography, and nuclear magnetic resonance, all of them performed in accordance with the methodologies of the official codes. The methods used have been found to be fast, efficient, reproducible and are suitable for the identification of celecoxib.
Results: Faster dissolution rate was exhibited by SD containing 1:5 ratio of celecoxib: PVP K-30 prepared by coevaporation method. In vitro drug release of celecoxib, gels revealed that formulation with HPMC has higher drug release as compared to Carbopol. Conclusion: The increase in dissolution rate for SD is observed in the following order of PVP K-30>urea>mannitol>PEG 6000. The CPD5 gel containing a SD CP5 and 20% DMSO showed the best in vitro release 74.13% at the end of 6 h.
Product Specification
| Item | Specification | Result |
| Appearance | White to off-white Powder | Conforms |
| Specific Rotation[α]D20 | -84.5°~ -86.0° | -84.7° |
| State of Solution | NLT98.0% | 98.65% |
| Chloride | NMT 0.020% | NMT0.020% |
| Ammonium | NMT0.02% | NMT 0.02% |
| Sulphate | NMT0.020% | NMT 0.020% |
| Iron | NMT10ppm | NMT10ppm |
| Heavy Metals (Pb) | NMT10ppm | NMT10ppm |
| Arsenic | NMT1ppm | NMT1ppm |
| Other Amino Acids | Chromatographically not detectable | Conforms |
| Loss on Drying | NMT0.30% | 0.20% |
| Residue on Ignition | NMT0.10% | 0.05% |
| Assay | 99.0% ~101.0% | 99.50% |
| PH | 5.9~6.9 | 6.0 |
| Conclusion | Conform with the enterprise standard | |
How To Obtain Samples Celecoxib powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API Celecoxib powder.
The Best Celecoxib powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Celecoxib powder?
Faithfulbio specialize in Celecoxib powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use Celecoxib powder for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Celecoxib powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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