Erythromycin estolate powder is a derivative of erythromycin, a macrolide antibiotic that appears as white crystals, almost odorless, with a melting point of 132-138 ℃. It is soluble in ethanol or chloroform and almost insoluble in water. This product is used for research on various bacterial infections.
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Item |
Standard |
Test Results |
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Appearance |
White crystalline powder |
Conform |
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Smell |
Characteristic odor |
Characteristic odor |
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Purity(Normalization method) |
≥99.96%,HPLC |
99.994% |
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Melting Point(Decomposition) |
132-138 ℃ |
133 |
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Optical Rotation |
[α]D≥(+)122∘(c=1,H2O) |
125.6∘ |
|
Loss on Drying |
≤0.2% |
0.02% |
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Elemental Analysis |
C:47.14±0.3% H:6.59±0.3% N:18.33±0.3% |
C:47.19% H:6.39% N:18.36% |
|
As |
≤0.1 ppm |
Negative |
|
Pb |
≤0.1 ppm |
Negative |
|
Hg |
≤0.1 ppm |
Negative |
|
Cd |
≤0.1 ppm |
Negative |
|
Total Heavy Metals |
≤10 ppm |
0.23ppm |
|
Total Residual Solvents |
<300 ppm |
10.71 ppm |
|
E.coli |
Negative/25g |
Conform |
|
Staphyloccocus aureus |
Negative/25g |
Conform |
|
P.aeruginosa |
Negative/25g |
Conform |
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Total Yeast and Mold Count |
≤10 CFU/g |
Conform |
|
Total Viable Aerobic Count |
≤100 CFU/g |
0.32 CFU/g |
|
Conclusion： |
Conform with enterprise specification . |
What is the difference between erythromycin estolate and azithromycin?
Although Erythromycin estolate and azithromycin are both macrolide antibiotics, But there are some differences between the two in a considerable part.
The difference between Erythromycin estolate and azithromycin:
1. Generation: Erythromycin estolate belongs to the early first generation of macrolide antibiotics,It has antibacterial activity against Staphylococcus, Streptococcus, and Gram positive bacteria. while azithromycin belongs to the second generation of antibiotics.It has antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, and Klebsiella pneumoniae.
2. Antibacterial effect: The antibacterial spectrum between the two is basically the same, but azithromycin has a wider and stronger antibacterial effect and range. If clinical treatment needs to be chosen, azithromycin is the first choice.
3. Drug half-life: Azithromycin has a relatively short medication time and a long half-life; However, the efficacy of erythromycin estolate is relatively weak, and the duration of drug use will be longer.
4. Applicable population: Erythromycin estolate is mainly used for patients with penicillin allergy, acute tonsillitis, acute pharyngitis caused by hemolytic streptococcus, pneumococcal streptococcus, etc. Azithromycin is used to treat patients with acute pharyngitis, acute tonsillitis, and other conditions caused by pyogenic streptococcus.
5. Efficacy time: The efficacy time of erythromycin estolate usually lasts for about 8 hours, while the efficacy time of azithromycin can reach about 24 hours.
6. Taboo population: Patients who are allergic to erythromycin estolate should be prohibited from using erythromycin estolate when using it. When using azithromycin for treatment, patients allergic to azithromycin, erythromycin estolate, and other macrolides should be prohibited from using it. Patients with a history of liver dysfunction should also be prohibited from using it.
Common adverse reactions of erythromycin estolate and azithromycin:
1. Gastrointestinal reactions: symptoms such as diarrhea, nausea, vomiting, upper abdominal pain, and decreased appetite.
2. Liver function impairment: It may lead to liver damage in patients, which may manifest as elevated transaminase levels and abnormalities in other liver function indicators.
3. Allergic reactions: may cause patients to experience drug fever, rash, and other related allergic reactions, and relying on erythromycin may also lead to individual patients experiencing arrhythmia.
Our company can provide various high-quality products such as Erythromycin Esterate and Azithromycin. If you are interested, please contact us via email: sales6@faithfulbio.com
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| 3521-62-8 Erythromycin Estolate | 83905-01-5 azithromycin |
What should we pay attention to when Lubomycine B tablets's production and use?
Erythromycin estolate is dodecyl sulfate of erythromycin propionate, which is more stable than erythromycin in gastric acid. Relying on erythromycin tablets, its mechanism of action is to inhibit the protein synthesis of bacteria by targeting peptide chain transferase, so as to achieve the purpose of eliminating infection. But it also has great side effects, such as gastrointestinal discomfort, such as nausea, vomiting, diarrhea, etc. Allergic reactions, such as rash, urticaria and shock, may also lead to adverse reactions such as liver function damage, myopathy and hearing loss. Therefore, when using erythromycin tablets, we should pay special attention to the rules of drug use.
At present, the production process of this product is that erythromycin thiocyanate is used as the main raw material, acetone is used as the solvent, potassium carbonate is desulfurized and filtered in layers, then potassium carbonate is added for adsorption, dehydration and filtration, and then it is esterified with propionic anhydride, and then dodecyl sulfate solution is added to synthesize erythromycin estolate. However, erythromycin estolate tablets is generally a common tablet, and if its brittleness is not well controlled, it is easy to break, crack and crush, which will affect the quality of tablets. According to the relevant research, it is found that the dissolution of erythromycin estolate tablets depends on the firmness of erythromycin estolate tablets granules, and if the firmness of erythromycin estolate tablets granules is not well controlled, it will also affect the uniformity and stability of tablet quality, thus affecting the stability of drug efficacy. Therefore, choosing good raw materials is the key to making high-quality finished products.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price.Our company can provide various Erythromycin Esterate, Azithromycin etc, If you are interested, please contact us
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