Meloxicam Powder CAS 71125-38-7

Meloxicam Powder is a non-steroidal antipyretic, analgesic and anti-inflammatory drug, not a hormone drug, with strong anti-inflammatory, analgesic and antipyretic effects. It can selectively inhibit the activity of cyclooxygenase-2 (COX-2), thus blocking prostaglandin synthesis. The inhibition of prostaglandin biosynthesis in inflammatory sites is stronger than that in gastric mucosa or kidney. More secure than other NSaids. It is mainly used to relieve the symptoms of osteoarthritis, painful osteoarthritis, rheumatoid arthritis and joint stiffness spondylitis.

The mechanism of action of NSaids is to prevent the synthesis of prostaglandins (PGs), which cause inflammation, by inhibiting cyclooxygenase (COX). Cyclooxygenase (COX) is a membrane-bound serum protein and glycoprotein that catalyzes the oxidation of arachidonic acid (AA) to prostaglandin G2(PGG2) and the reduction from PGG2 to PGH2. There are two types of COX isomerization: cyclooxygenase-1 (COX-1) - structural enzyme and cyclooxygenase-2 (COX-2) - PGG2-induced enzyme. The inducible enzyme COX-2 is induced by the regulation of inflammation and is involved in the regulation of inflammatory response. The structural enzyme COX-1 is necessary for the normal physiological process and exists in most tissues. Its function is to synthesize PG to regulate the normal physiological activity of cells, protect the gastrointestinal mucosa, support the microcirculation in the kidney and protect other organs from destruction.