1-MNA Powder CAS 3106-60-3

1-MNA is a natural metabolite of vitamin B3 (niacin/nicotinamide) in the human body. It is an endogenous substance present in all living cells, and in current nutritional research, its level in urine excretion is used as one of the reference indicators for evaluating the nutritional status of nicotinamide. We provide 1-MNA powder that is the same as natural 1-MNA in the body, both of which can be excreted through urine and improve the nutritional status of niacinamide in the body. In recent years, it has become an important dietary supplement ingredient due to its unique anti-inflammatory and metabolic regulatory activities.

What is the mechanism of action of 1-MNA powder?

1-MNA does not directly convert into energy or NAD+. Its core mechanism of action is:
Inhibition of PARS enzyme: 1-MNA is a potent inhibitor of poly (ADP ribose) polymerase (PARS). When cells are damaged by factors such as oxidative stress, PARS is overactivated, consuming a large amount of cellular energy (NAD+and ATP), leading to cellular dysfunction or death. 1-MNA can effectively protect cellular energy, reduce oxidative stress and inflammatory response by inhibiting PARS.
Anti inflammatory effect: Through the above mechanism, 1-MNA can significantly reduce the levels of key pro-inflammatory factors (such as TNF - α, IL-6), thereby exerting a strong systemic anti-inflammatory effect.

What is the difference between 1-MNA powder and vitamin B3 derivatives such as NR and NMN?

Researchers believe that this is the most critical difference between them as endogenous substances:
I.1-MNA powder: Its main functions are anti-inflammatory and cell protective. It does not directly increase NAD+levels, but rather "saves" NAD+by inhibiting PARS, indirectly maintaining cellular energy homeostasis.
II.NR/NMN: Its main function is to act as a precursor of NAD+, directly increasing NAD+levels in the body, thereby activating Sirtuins longevity protein, which is mainly used to support cellular energy metabolism and anti-aging.
III.A simple analogy: NR/NMN is "open source" (increasing the generation of energy currency NAD+), while 1-MNA is "throttling" (preventing excessive consumption of energy currency NAD+). The two can synergistically support cellular health through different pathways.

What are the main benefits of 1-MNA powder?

Based on preclinical and clinical studies, the efficacy of 1-MNA includes:
1.Supporting cardiovascular health: improving endothelial function and reducing vascular inflammation.
2.Relieve joint discomfort: reduce inflammatory factors that cause joint cartilage degeneration.
3.Promote exercise recovery: reduce muscle inflammation and oxidative damage after intense exercise, and accelerate recovery.
4.Supporting liver health: has the potential to protect against alcoholic and non-alcoholic fatty liver disease.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide 1-MNA powder etc. at a more favorable price. If you are interested, please leave a message.
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FAQ:

Q1. What are the side effects or safety issues?
1-MNA powder has good overall safety as it is an endogenous substance. In clinical studies, its tolerability performance is excellent.
However, this does not mean that it is absolutely safe. Studies have shown that it may have the following mild side effects, especially in the early or higher doses: skin flushing (but much milder than niacin), gastrointestinal discomfort (such as nausea)
Important reminder: Pregnant women, lactating women, minors, and those who are currently using antiplatelet or anticoagulant drugs should consult a doctor before use.
Q2. How to store 1-MNA powder?
In high temperature and high humidity conditions, its stability will be greatly affected. So you should store it in a cool, dry, and dark place, preferably sealed and stored in its original packaging.
Q3.1-MNA is it a pharmaceutical ingredient or a dietary supplement?
At present, 1-MNA mainly appears in the market as a dietary supplement raw material or finished product. It has not been approved by any national drug regulatory agency (such as the US FDA) for use in certain diseases, although it can address certain disease issues. So when choosing and using, attention should be paid to discernment.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

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