6 Chloropurine CAS 87-42-3

6-Chloropurine is an orange solid at normal temperature and pressure. Pure 6- chloropurine belongs to purine compounds, which can be used as organic synthesis and biochemical intermediates, and can be used for biochemical research and modification and derivation of drug molecules and bioactive molecules. For example, 6 chloropurine is one of the main intermediates in the synthesis of adenine, for example, vitamin B4 (adenine phosphate).

Application conversion of 6-chloropurine.

6- chloropurine is widely used in the fields of medicine and agricultural chemicals. For example, it is the main raw material for synthesizing vitamin B4 (adenine phosphate). In addition, 6-chloroprene drug molecule adefovir dipivoxil is also used in the synthesis, and adefovir dipivoxil can effectively inhibit the replication of hepatitis B virus DNA strand.
So the application conversion of this product is very important.

1：In a dry reaction flask, 6-chloropurine (6.000 g, 39 mmol) was slowly dissolved in concentrated hydroiodic acid (45%, 50 mL) at 0 ° C. The resulting reaction mixture was stirred at 0 ° C for 3 hours. After the reaction is complete, the precipitate in the reaction is collected by filtration, and then the filter cake is suspended in ice cold water. The pH is adjusted to 7.5 with 5% ammonia water, and the precipitate is collected again by filtration. The filter cake is washed with clean water, and the mixture is vacuum dried to obtain the dechlorinated and iodinated product molecule 6-iodopurine.

2：In a dry reaction flask, hydrazine hydrate (0.116 mL, 2 mmol) was added to a solution of 6-chloropurine (1 mmol) in ethanol (15 mL). The resulting reaction mixture was stirred at room temperature for a period of time, and then heated and stirred at reflux temperature for 2 hours. After the reaction was complete, the precipitate was filtered and washed with ethanol (10 mL), dichloromethane (10 mL), and ether (10 mL) to obtain the derivative molecule of 6-chloropurine chloride substituted with hydrazine.

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