what is Dynorphin A (1-13) Acetate?
Dynorphin A (1-13) Acetate is a short peptide fragment derived from the precursor protein of Dynorphinogen. It is the N-terminal 13 amino acid sequence of Dynorphin A and is considered the core region for its biological activity. Its essence is a neuropeptide that naturally exists in the central nervous system of mammals (including humans). The appearance of Dynorphin A (1-13) Acetate is a white powder.
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Product name |
Dynorphin A (1-13) Acetate |
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CAS |
72957-38-1 |
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Molecular formula |
C75H126N24O15 | |
| EINECS | 635-974-1 | |
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Molecular weight |
1603.95 | |
| Storage | -20°C | |
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Density |
1.39±0.1 g/cm3(Predicted) | |
| Appearance | White powder |
What are the main uses of Dynorphin A (1-13) Acetate?
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Dynorphin A (1-13) Acetate raw powder is currently limited to scientific research use only Its main uses in the field of scientific research include: Neuroscience research: Used to study the distribution, activation mechanism, and downstream signaling pathways of its receptors. Explore its role in pain regulation, emotional control, reward mechanisms, and stress response. Study its potential role in neurodegenerative diseases such as Alzheimer's disease. Pharmacological research: As a tool drug, it is used to screen and evaluate the activity of novel receptor agonists or antagonists. Study the possible side effects of receptor agonists, such as sedation and irritability, to provide a basis for developing analgesics with fewer side effects. Research on pain management mechanism: Due to its powerful analgesic potential, scientists are using it to explore pain relief pathways different from traditional analgesics, in order to develop non addictive or low addictive new analgesics. |
Product Specification
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Item |
Specification |
Result |
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Appearance |
White powder |
Complies |
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Identification |
Positive |
Complies |
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Assay |
98.0% Min |
98.6% |
| Conclusion： Conform with enterprise specification . | ||
what is the mechanism of action of Dynorphin A (1-13) Acetate?
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The mechanism of action of Dynorphin A (1-13) Acetateis mainly achieved through selective activation of receptors. Receptor binding: Dynorphin A (1-13) acts as a ligand and specifically binds to G protein coupled receptors on the cell membrane. Signal transduction: After binding, it inhibits the activity of Adenylate cyclase and reduces the level of intracellular cyclic adenosine monophosphate (cAMP). Ionic channel regulation: At the same time, it activates the intracellular second messenger system, leading to the closure of voltage-gated calcium channels and promoting the opening of potassium channels. Physiological effects: Reduced calcium influx: The decrease in calcium ion influx leads to a decrease in neuronal excitability, and the release of neurotransmitters such as glutamate and substance P is inhibited. Increased potassium efflux: Increased potassium ion efflux causes cell membrane hyperpolarization, further inhibiting neuronal electrical activity. The final result: In specific regions of the spinal cord and brain, this extensive inhibition of neuronal activity ultimately produces a strong analgesic effect. |
How and where to Buy Dynorphin A (1-13) Acetate?
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q:What is its analgesic effect of Dynorphin A (1-13) Acetate?
A:In animal experiments, dynorphin A (1-13) has indeed shown stronger analgesic efficacy in certain pain models. However, the side effects associated with its analgesic properties, such as sedation and irritability, limit its direct clinical application.
Q:What is the amino acid sequence of Dynorphin A (1-13) Acetate?
A:H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH.
Q:Is Dynorphin A (1-13) Acetate water-soluble?
A:Yes, it is water-soluble.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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