Dacarbazine Pharmaceutical Raw Materials CAS 4342-03-4

What is Dacarbazine?

Dacarbazine Pharmaceutical raw Materials is a new type of purine precursor anti-tumor drug, which can interfere with the biosynthesis of purine and also act as an alkylating agent. It has an inhibitory effect on mouse sarcoma-180, lung cancer-755, melanoma B16, and leukemia L-1210. It acts on the G2 phase of the cell cycle, mainly affecting RNA and protein synthesis, followed by DNA. Oral absorption is incomplete, and individual differences are large. After 1 intravenous injection, the peak value was reached in 30min and disappeared in 6h. 30% of the dose was excreted in the urine in 6h. Cannot pass the blood-cerebrospinal fluid barrier.

Dacarbazine Benefits

Dacarbazine Pharmaceutical raw Materials are mainly used in:

Mainly used for malignant melanoma, better than hydroxyurea, such as combined with vinblastine, carmustine can improve the efficacy. Also used for lung squamous cell carcinoma and undifferentiated carcinoma, leiomyosarcoma, fibrosarcoma, and so on. Ineffective for gastrointestinal tumors.

Application of Dacarbazine

Because oral absorption is incomplete and variable, dacarbazine is administered intravenously only. It is first converted to the monomethyl form by N-demethylation in the liver and then metabolized to aminoimidazole carboxamide (AIC) and diazomethane. Active carbon ions are formed from diazomethane. Dacarbazine has a biphasic plasma decline; half-lives are 19 minutes and 5 hours. It is quickly excreted by renal tubular secretion. About 40% is excreted in unchanged form within 6 hours, and the major metabolite in urine is AIC.

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How To Obtain Samples of Dacarbazine?

Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API powder Dacarbazine.

The Best Dacarbazine Manufacturer And Supplier

Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.

We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.

Why Choose Faithfulbio Dacarbazine?

Faithfulbio specialize in Dacarbazine for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.

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kindly note: Use this compound for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.

Where To Buy Dacarbazine?

Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!

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