Cyclophosphamide Powder is one of the most commonly used alkylating agents for anti-tumor drugs. It is a white crystal or crystalline powder at room temperature (it will be liquefied when crystal water is lost), and it is stable at room temperature. Soluble in water, but not very soluble. The aqueous solution is unstable, so it should be used shortly after dissolution. Soluble in ethanol. Odorless, slightly bitter, 1g dissolved in 25ml of water or 1ml of ethanol at 20℃. It was first synthesized by Arnold and Bourdeaux in 1958. The synthesis of this compound and its derivatives was based on the structure and function of previous anticancer drugs. It is mainly used for tumor immunity. After it enters the human body, it decomposes and releases chloroethyl phosphoramide (or phosphamide nitrogen mustard) with strong alkylation under the catalysis of the liver microsomal enzyme, which produces a cytotoxic effect on tumor cells and has an obvious inhibitory effect on many kinds of tumors. In recent years, it has been proved to have an immunosuppressive effect and has been used for the treatment of many autoimmune diseases, and has achieved obvious curative effects.
What is Cyclophosphamide?
Cyclophosphamide powder has no alkylation and cytotoxicity. After being absorbed by the body, it metabolizes in the liver to produce active metabolites, which play a role. Cyclophosphamide has a broad anticancer spectrum, is effective for leukemia and solid tumors, and can be used as an immunosuppressant to treat various autoimmune diseases.
Cyclophosphamide is a prodrug that can be converted into an active form in the liver and other organs.
Although cyclophosphamide is very effective, it may have short-term and long-term disastrous toxic effects. Concerns about the toxic effects of these drugs (especially malignant tumors) limit their use in patients with the most serious diseases.
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Real shot pictures of Cyclophosphamide raw powder | Cyclophosphamide structure diagram |
How does Cyclophosphamide work?
Cyclophosphamide powder is a non-specific cytotoxic drug in the cell cycle, but it has a stronger effect on the G2 phase (the late stage of DNA synthesis). The main immunosuppressive mechanism is:
① The absolute number of T and B lymphocytes decreased, especially in the early stage.
② significantly inhibit the transformation of lymphocytes into mother cells stimulated by specific antigens. The inhibition of mitogen stimulation is not as good as that of specific antigens.
③ Inhibit the antibody reaction to the new antigen and skin delayed allergy.
④ Reducing the elevated immunoglobulin level may lead to hypogammaglobulinemia after long-term use.
⑤ Selectively inhibit the function of B lymphocytes in vitro, reduce the spontaneous production of immunoglobulin by some B lymphocytes, and inhibit the production of immunoglobulin by general mitogen stimulation.
What are the side effects of Cyclophosphamide?
1. Bone marrow suppression, mainly leukopenia.
2. Urinary tract symptoms mainly come from chemical cystitis. You should drink more water and increase urine volume to relieve symptoms.
3. Digestive symptoms include nausea, vomiting, and anorexia.
4. The common skin symptom is alopecia, but tiny new hair can be regenerated after stopping the drug.
5. In Long-term application, men can cause testicular atrophy and sperm deficiency; Women can cause amenorrhea, ovarian fibrosis, or teratogenicity. Use with caution by pregnant women.
6. Occasionally, liver function may be affected, resulting in jaundice and reduction of prothrombin. Use it with caution for those with poor liver function.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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