Gemcitabine HCl API Powder CAS 122111-03-9

Gemcitabine HCl API Powder is white to light yellow powder, melting point: > 250°C dec, solubility: H2O: ≥10mg/mL. It is similar to cytarabine and is an analog of deoxypyrimidine. It is used to treat inoperable advanced or metastatic pancreatic cancer and locally advanced or metastatic non-small cell lung cancer.

Gemcitabine HCl API Powder is a new synthetic difluoro nucleoside antimetabolite and antineoplastic drug. It was approved for marketing in South Africa, Sweden, the Netherlands, Australia, and other countries in 1995. In 1996, FDA approved it for clinical use as the first-line treatment for non-small cell lung cancer and pancreatic cancer.

What is Gemcitabine HCl?

Gemcitabine HCl API Powder, as a prodrug, is a good substrate for phosphorylation of deoxythymidine kinase in cells.

Gemcitabine hydrochloride is a new generation of antimetabolite, a cell cycle-specific drug, which mainly acts on the DNA synthesis phase, that is, S phase cells. Under certain conditions, it can also prevent the progression from the G1 phase to the S phase, and it has strong anticancer activity against NSCLC. Foreign studies show that the effective rate of gemcitabine hydrochloride alone in the treatment of NSCLC is 18% ~ 35%. The effective rate of cisplatin in the treatment of NSCLC was 41.7%. The effective rate of carboplatin for advanced NSCLC is 16%, and its curative effect is similar to cisplatin, but its toxicity is low, especially in the digestive tract, bone marrow suppression, and kidney, and peripheral nerves. Combined with carboplatin, it has mutual coordination and additive effect and can produce a higher curative effect.

What are the effects of gemcitabine hydrochloride?

1. Pancreatic cancer with locally advanced lesions or metastatic pancreatic cancer can also be used for pancreatic cancer that is ineffective with 5-FU.

2. Locally advanced or metastatic non-small cell lung cancer.

What are the side effects of using Gemcitabine hydrochloride?

1. Blood system

It can inhibit bone marrow and can cause anemia, leukopenia, and thrombocytopenia.

2. Gastrointestinal tract

About 1/3 of patients have nausea and vomiting, and 20% of patients need medical treatment, which is easily controlled by anti-vomiting drugs.

3. Kidney

About 1/2 of the patients had mild proteinuria and hematuria, some cases had unexplained renal failure, and no cumulative renal toxicity was observed.

4. Allergies

About 25% of patients have skin diagnoses, 10% have itching, and less than 1% have bronchospasm.

5. Other

About 20% of patients have flu-like symptoms.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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