What is Nilotinib powder?
Raw material Nilotinib powder is a novel targeted tumor therapy agent, which belongs to a tyrosine kinase inhibitor, and has shown remarkable efficacy in the treatment of chronic myeloid leukemia (CML) patients who are resistant to Gleevec (imatinib). Gleevec is the drug of choice developed by Novartis for the treatment of chronic myelogenous leukemia (CML). Nilotinib is derived from the improved molecular structure of imatinib and has a stronger selectivity to BCR-ABL kinase activity. Its inhibitory effect on tyrosine kinase is 30 times stronger than that of imatinib, and it can inhibit the kinase activity of the PCR-ABL mutant that is resistant to imatinib. It also inhibited KIT and PDGFR kinase activity.
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| Raw material Nilotinib Picture | Raw material Nilotinib MF |
Nilotinib powder Benefits
Raw material Nilotinib powder is mainly used in:
Treatment of chronic adult chronic myelogenous leukemia with newly diagnosed Philadelphia chromosome-positive (Ph+).
treatment of Philadelphia chromosomal positive chronic myelogenous leukemia in the acute and accelerated stages.
to treat chronic myeloid leukemia that has been treated with interferon.
to treat pediatric chronic myelogenous leukemia with recurrence after myelosuppression or ineffective treatment with interferon.
Treat inoperable or metastatic malignant GASTROINTESTINAL stromal tumors that are KIT(CD117) positive.
Application of Nilotinib powder
It acts on activated HSCs and inhibits proliferation, migration, and actin formation, as well as α-SMA and collagen expression. Nilotinib induced apoptosis of HSCs, which was associated with decreased expression of Bcl-2 and increased expression of p53, PARP division, PPARγ, and TRAIL-R. Nilotinib also induces cell cycle arrest, with p27 expression and cyclinD1 down-regulated. Nilotinib not only inhibits PDGFR activation but also inhibits TGFRII via Src. Nilotinib significantly inhibited PDGF and TGFβ -stimulated ERK and Akt phosphorylation.
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How To Obtain Samples of Nilotinib powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API powder Nilotinib powder.
The Best Nilotinib powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Nilotinib powder?
Faithfulbio specialize in Nilotinib powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
Transportation Time | Shipping method | Cargo weight requirements | Advantage |
3-7 days | DHL,Germany DHL,Germany DPD, | Suitable for under 50kg. | We have warehouses in Germany and California, the USA, |
7-15 days | By Air | Suitable for more than 50kg. | |
15-60 days | By Sea | Suitable for more than 500kg. |
kindly note: Use this compound for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Nilotinib powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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