Flutamide powder is a dark yellow or yellow powder, CAS:13311-84-7, molecular formula: C11H11F3N2O3, melting point: 112 °C, boiling point: 400.3±45.0 °C(Predicted). It is easily soluble in methanol, ethanol, or acetone, soluble in chloroform, and almost insoluble in water.
Flutamide is a non-steroidal antiandrogen. According to the data, flutamide has antiandrogen and anti-tumor effects and has a good prospect in the treatment of androgen-related diseases such as prostate cancer, prostatic hyperplasia, and ovarian cancer. Transdermal drug delivery has the advantages of avoiding the first-pass effect on the liver, the degradation and absorption of drugs in the gastrointestinal tract are not affected by gastrointestinal factors, and there are no gastrointestinal adverse reactions.
What is Flutamide?
Flutamide powder is an anti-tumor drug originally developed by Schering‑Plough Company in the United States. It was first marketed in 1984 and can be used for the treatment of prostate cancer and adjuvant treatment of prostatic hypertrophy. It competes with androgen for the androgen receptors in the tumor site, blocks the uptake of androgen by cells, and inhibits the combination of androgen with target organs. After binding with the androgen receptor, it forms a receptor complex, enters the nucleus, and binds with nuclear protein, thus inhibiting the growth of tumor cells.
Flutamide is the first-line treatment for prostate cancer. Because flutamide itself has no hormone activity, it has a good therapeutic effect on prostate diseases, has no influence on the cardiovascular system, can maintain the sexual function of patients, and can also be used for androgen-related non-prostate diseases, which has been extensively studied internationally.
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Real shot pictures of Flutamide raw powder | Flutamide structure diagram |
What are the uses of flutamide?
1. Flutamide powder is suitable for the treatment of prostate cancer and prostatic hypertrophy.
2. Non-steroidal androgen antagonists can inhibit the conversion of testosterone into dihydrotestosterone, and block the combination of dihydrotestosterone with nuclear receptors in the prostate at the cellular level, thus inhibiting the growth stimulation of androgen in the prostate.
3. It is used for the treatment of prostate cancer and prostatic hypertrophy and the combination of luteinizing hormone-Lian Pu, which can treat advanced prostate cancer and prostatic hypertrophy.
4. It is used to treat advanced prostate cancer and prostatic hypertrophy which can't be treated by surgery or radiotherapy.
What are the adverse reactions when using flutamide?
1. Feminization of male breasts, tenderness of breasts, sometimes accompanied by galactorrhea, can disappear if the dosage is reduced or the drug is stopped.
2. A few patients may have diarrhea, nausea, vomiting, increased appetite, insomnia, and fatigue.
3. Rare decrease in sexual desire, transient abnormal liver function, and decreased sperm count.
4. Its potential impact on the cardiovascular system is less than that of diethylstilbestrol.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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