98% Nuciferine Powder CAS 475-83-2

98% Nuciferine powder is easily soluble in organic solvents with low polarities such as benzene, ether, chloroform, and haloalkane, but also has good solubility in hydrophilic organic solvents such as acetone and ethanol, while its solubility in water is small or almost insoluble, which comes from the dried leaves of Nelumbo Nuciferine, a plant of Nymphaeaceae. The high-purity nuciferine is beige to white-like crystalline powder, and the higher the purity, the lighter the color.

What is Nuciferine?

98% Nuciferine powder is an apomorphine alkaloid extracted from dried leaves of Nelumbo nucifera Gaertn. It is the main lipid-lowering active ingredient in lotus leaves. It is extracted from sun-dried and crushed lotus leaves by cellulase pretreatment, dilute hydrochloric acid extraction, ultrasonic-assisted extraction, and chloroform extraction. Traditional Chinese medicine believes that lotus leaves are bitter and flat in nature and belong to the liver, spleen, stomach, and heart meridian. It has the effects of clearing summer heat and promoting diuresis, raising hair and clearing yang, cooling blood, and stopping bleeding. The main chemical components of lotus leaf are nuciferine, citric acid, oxalic acid, etc., and nuciferine plays a major role in reducing weight. Pharmacological studies show that the lotus leaf has the functions of diuresis, relaxing bowels, reducing fat and removing oil, clearing away summer heat, relieving fever, etc., can significantly reduce the content of triglyceride and cholesterol in serum, and has the health care function of regulating blood lipid. Using lotus leaves to lose weight doesn't require deliberate dieting and has no side effects on the human body.

What is the significance of Nuciferine research?

98% Nuciferine powder has lipid-lowering weight loss, antibacterial, antioxidant, antiviral, and other effects, and as a natural product, Cetilistat has the safety that other drugs do not have, which makes lotus leaf alkaloids have great application potential. However, it also has problems such as poor solubility and low bioavailability, which limit its further utilization. Therefore, it is of great significance to explore to improve the solubility, stability, and bioavailability of lotus leaf alkaloids. Scientists took it as a research object and prepared two nanocarriers, liposomes and phospholipid-chitosan self-assembled nanoparticles, to encapsulate Cetilistat. The prepared nanocarriers were characterized by combining chromatography, differential scanning calorimetry, infrared spectroscopy, and transmission electron microscopy; storage stability experiments, digestion stability experiments, and in vitro simulated release experiments were designed to study the embedded nanoparticles. properties and designed animal experiments to verify the improvement of liposomes for its oral bioavailability, thus further confirming the value of cetilistat.

Where are the benefits of Nuciferine used?

1. Nuciferine effectively inhibits HFD-induced weight gain

Nuciferine is an aporphine-type alkaloid in the lotus leaf, which is the main lipid-lowering active ingredient in the lotus leaf. The researchers found that a certain dose of Nuciferine treated high-fat-fed experimental mice significantly inhibited the weight gain trend, which was more effective than the drug simvastatin (2.6mg/kg).

2. Elimination of intestinal flora will eliminate the anti-lipid effect of Nuciferine

The researchers used antibiotics to eliminate gut microbes to assess the gut microbiota's involvement in Nuciferine's lipid-lowering effects and to compare what effects Nuciferine had in conventional and antibiotic-induced pseudo-germ-free mice. The results demonstrated that the beneficial effects of Nuciferine were largely inhibited when 7.5-30 mg/kg of Nuciferine was combined with antibiotics. This is because antibiotics reduce gut microbial abundance, thereby eliminating the preventive effect of Nuciferine on HFD-induced obesity.

3. Effects of different agents on intestinal flora

The microbiota affects the entire gut ecosystem. In order to confirm the effect of Nuciferine on the host, the researchers used "whole metagenomic shotgun" sequencing to reveal the changes in the intestinal microbiota of mice caused by different agents.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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