Agomelatine powder is the world's first melatonin receptor MT1 and MT2 agonist antidepressant, which is suitable for the treatment of major depressive episodes in adult patients. Pure Agomelatine is a white to white powder. As a new antidepressant, it has the function of regulating biological rhythm while exerting antidepressant effect.
| structural formula |
|
|
|
Test Items |
Standards |
Results |
|
Appearance |
White to off white crystalline powder |
Conforms |
|
Identification |
The retention time of the peak for alpha lipoic acid in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay. |
Conforms |
|
Melting point |
107～110℃ |
108.5℃ |
|
Heavy metals |
≤20ppm |
＜10ppm |
|
Loss on drying |
≤0.5% |
0.4% |
|
ignition residue |
≤0.1% |
0.07% |
|
Related compounds |
≤0.1% |
Conforms |
|
Total impurities |
≤0.3% |
Conforms |
|
Assay |
99.0%～101.1% |
99.95% |
|
Conclusion |
Confirms to Standards |
|
What are the pharmacological studies of agomelatine?
The mechanism of action of most antidepressants currently used is based on regulating the monoamine neurotransmitter system, mainly by increasing the levels of neurotransmitters such as serotonin (5HT), norepinephrine (NE), and dopamine (DA) to alleviate symptoms of low mood. However, their therapeutic effect on lack of interest, fatigue, sleep, and cognitive dysfunction is minimal. These residual symptoms, accumulated or stimulated, often lead to disease relapse or chronicity, affecting patients' work and social abilities, resulting in a decline in their quality of life and social function. Agomelatine powder is a new breakthrough in this field. It is both a melatonin MT1/MT2 receptor agonist and a serotonin 2c (5-HT2C) receptor antagonist. Through the synergistic effect of the two, it restores the disrupted circadian rhythm of depression patients and produces antidepressant efficacy. Its unique mechanism of action allows this product to exert antidepressant efficacy while maximizing the solution to the problem of the causal relationship between the quality of sleep and the outcome of depression.
This product has a good repairing effect on damaged neurons.
Animal research results show that agomelatine can not only correct the circadian rhythm of animal models with disrupted circadian rhythms, but also reconstruct the circadian rhythm. And there is evidence to suggest that it can also increase the plasticity and neuronal proliferation of hippocampal neurons. The proliferation, regeneration, and death of nerve cells in the brain of adult rats were determined by immunostaining. The results showed that long-term (3 weeks) use of agomelatine increased cell proliferation and neuronal regeneration in the ventral dentate gyrus of the hippocampus, which is related to emotional responses. But similar situations were not observed in acute or subacute cases. After further extension of time, cell proliferation and neuronal regeneration were observed throughout the entire dentate gyrus region.
This indicates that agomelatine powder can increase neural regeneration in the hippocampus to varying degrees, thereby producing new granulosa cells.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Agomelatine powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
Hot Tags: agomelatine powder cas 138112-76-2, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China