what is Epirubicin Hydrochloride?
Epirubicin hydrochloride is the main isomer of doxorubicin, which is the trans configuration of the C4 hydroxyl group in the amino sugar portion of doxorubicin. It can be directly embedded into DNA, form complexes with the double helix structure of DNA, block DNA dependent RNA formation, and has the kinetic energy to form superoxide radicals. Single drug has broad-spectrum inhibitory effect on a variety of tumors, including breast cancer, malignant lymphoma, soft tissue sarcoma and gastric cancer. Research has shown that the drug also has anti-tumor activity against malignant melanoma and colon cancer.
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Product name |
Epirubicin hydrochloride |
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CAS |
56390-09-1 |
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Molecular formula |
C27H30ClNO11 |
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Molecular weight |
579.9802 |
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EINECS Number |
260-145-2 |
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Storage condition |
Inert atmosphere,Store in freezer, under -20°C | |
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Appearance |
Red powder |
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Melting point |
185°C dec. | |
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Solubility |
Dissolve in DMSO to 100mM, or dissolve in ethanol to 10mM |
Is the clinical application of epirubicin hydrochloride widespread?
It is widely used clinically and is mainly used to treat various solid tumors such as acute leukemia and malignant lymphoma, breast cancer, bronchial lung cancer, ovarian cancer, nephroblastoma, soft tissue sarcoma, bladder cancer cancer, testicular cancer, prostate cancer, gastric cancer, liver cancer (including primary hepatocellular carcinoma and metastatic cancer), and thyroid adenomedullary carcinoma.If you need epirubicin hydrochloride,you can Click email：sales1@faithfulbio.com
What are the pharmacological effects of epirubicin hydrochloride?
Epirubicin hydrochloride is the main isomer of doxorubicin, which is the trans configuration of the C4 hydroxyl group in the aminoglycoside of doxorubicin. Its main mechanism of action is to directly insert into adjacent base pairs of DNA, form reversible binding with the DNA double helix, interfere with the transcription process, thereby inhibiting the synthesis of DNA and RNA, and achieving the goal of treating tumors. In addition, epirubicin hydrochloride has an inhibitory effect on topoisomerase II, can also act on the nucleus, and can affect the cell membrane and its operating system of tumor cells. It is a non-specific drug for the cell cycle and is effective against various transplanted tumors.
What is the Pharmacokinetics of epirubicin hydrochloride?
The tissue distribution of Epirubicin hydrochloride is similar to that of doxorubicin. After 1 hour, 24 hours, and 48 hours of administration, the concentration in the heart, spleen, and kidneys is lower than that of doxorubicin after 48 hours. At 24 and 48 hours, the concentration of in tumors was significantly lower than that of doxorubicin. The half-life of plasma is 30 hours, mainly excreted through the biliary tract. 10% is excreted in the urine within 48 hours, and 40% is excreted within 4 days. The vast majority is excreted in its original form and in combination with glucuronic acid.
Product Specification
| Analysis tests | Standard | Result |
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Appearance |
red powder |
Conforms |
| Identification | HPLC | Conforms |
| Water | ≤8% | 0.8% |
| Specific rotation | +310 to +340 deg(C=0.05, methanol)(calcd.on anh.substance) | 330deg |
| Purity | ≧95% | 98.4% |
Conclusion：Conform with specification and qualified.
What are the interactions with other drugs?
1. It has synergistic effects and toxicity with other anticancer drugs, and should be avoided from contact or administered in the same container. Combination use should be reduced.
2. Avoid using non essential drugs that may cause liver, kidney, and heart damage.
3. This product suppresses immune responses and should not be used in conjunction with live vaccines.
4. Chest radiotherapy can exacerbate the myocardial damage caused by this drug.
5. When used in combination with nitrosamines and mitomycin that severely inhibit bone marrow, the dosage should be reduced accordingly.
How and where to buy epirubicin hydrochloride wholesale?
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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