Overview of Ifosfamide：
Ifosfamide is a cyclophosphamide isomer, which is white crystal or crystalline powder at room temperature. The difference from cyclophosphamide is that the position of chloroethyl is different, and it is also a latent drug, which needs to be activated by the liver after entering the body.
Ifosfamide Powder is White to off-white,Inert atmosphere,2-8°C.
| Product name | Ifosfamide |
| CAS | 3778-73-2 |
| Molecular formula | C7H15Cl2N2O2P |
| Molecular weight | 261.09 |
| EINECS Number | 223-237-3 |
| Melting point | 48°C |
| boiling point | 336.1±52.0 °C(Predicted) |
| Appearance | White to off-white |
| Storage condition | Inert atmosphere,2-8°C |
| Density | 1.33±0.1 g/cm3(Predicted) |
What is ifosfamide?
Isophosphamide is a white crystalline porous mass or powder, and its anti-tumor spectrum is wide. The main indications are soft tissue tumor, testicular tumor, malignant lymphoma and so on.
Ifosfamide is a derivative of phosphoramide
Ifosfamide is a derivative of phosphoramide, which has been widely used at present. Mainly for all kinds of solid tumors or some leukemia, can achieve a certain therapeutic effect. Ifosfamide Powder also has a certain therapeutic effect on non-small cell lung cancer, breast cancer, esophageal cancer, or sarcoma of bone and soft tissue.
product Specification
| Item | Specification | Results |
| Appearance | white powder | Complies |
| Odor | Characteristic | Complies |
| Assay | 99% | 99.38% |
| Loss on Drying | ≤1.0% | 0.3% |
| Residue on Ignition | ≤1.0% | 0.09% |
| Heavy Metal | <2ppm | 0.5ppm |
| Arsen | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Conclusion: The test results are conformed to the in-house specification | ||
What is the pharmacological action of ifosfamide?
After 17 years of clinical verification since 1971, the United States was approved by the US FDA in December 1988, and Ifosfamide/Sodium Mercosulfonate (I/M) went on the market, and it was listed as the highest grade 1A antineoplastic drug. It is an alkylated oxygen, nitrogen and phosphorus ring drug similar in structure to cyclophosphamide.
Ifosfamide is a prodrug, which is converted into a metabolite with cytotoxic activity by enzymes in the liver.
Its mechanism of action is similar to other alkylating agents, and it has been proved in various experimental tumor systems that it is more active than cyclophosphamide in leukemia L1210. Ifosfamide Powder is also active in ascites carcinoma resistant to anthracyclines and cyclophosphamide. This shows that the curative effect of treating ascites sarcoma in rats reaches the therapeutic index of cyclophosphamide.
Ifosfamide is more effective than cyclophosphamide in treating C3H breast tumor, osteosarcoma, natural high drug resistance DS- cancer and TA- neuroblastoma in rats.
In the L1210 model of advanced leukemia, ifosfamide has synergistic effect with cisplatin, cytarabine and fluorouracil, but not with cyclophosphamide.
Ifosfamide Powder combined with vincristine is more effective than either drug alone in prolonging the survival time of Yoshida ascites sarcoma animals. In nude mice, isocyclic phosphoryl is the most effective for human breast, lung and testis xenografts and sarcomas, but not for ovarian, uterine, pancreatic and renal cancer xenografts. Ifosfamide has high effective rate.
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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