Mitoxantrone Hydrochloride Introduction
Mitoxantrone HCL powder is Purple brown, and its solution is a dark blue clear liquid. Mitoxantrone hydrochloride is a dark powder, with CAS number: 70476-82-3, and its molecular formula is: C22H30Cl2N4O6. Molecular weight: 517.4028; EINECS: 274-619-1, slightly soluble in water.It is mainly used for the treatment of malignant lymphoma, breast cancer, and acute leukemia. This product is a cell cycle nonspecific drug, which can inhibit nucleic acid synthesis and lead to cell death by binding with DNA molecules. For lung cancer, melanoma, soft tissue sarcoma, multiple myeloma, liver cancer, colorectal cancer, and other diseases. Because it has no complete cross-resistance with anthracycline drugs, it also has a certain effect on the treatment of renal cancer, prostate cancer, endometrial cancer, testicular tumor, ovarian cancer, and head and neck cancer.
| Molecular formula |
| |
| Item | Standard | Test Results |
| Appearance | White powder | Conforms |
| Identification (IR) | Concordant with reference spectrum | Conforms |
| Assay | ≥99.0% | 99.2% |
| Water | <2.0% | 0.4% |
| Residual solvent | <1.0% | 0.2% |
| Heavy Metals | ≤15 | 10 |
| Loss on Drying | ≤0.3% | 0.04% |
| Residue on Ignition | ≤0.3% | 0.08% |
| Chromatographic purity | Meets the requirements | Conforms |
| Organic volatile impurities | Meets the requirements | Conforms |
| Microbial assessment | Compliance with indicators | Conforms |
| BSE | not detected | not detected |
| GMO | not detected | not detected |
| Allergen | not detected | not detected |
| Radiation | not detected | not detected |
| Conclusion： | Conform with enterprise specification . |
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What are the pharmacological effects of Mitoxantrone hydrochloride?
Mitoxantrone HCL powder is a new anthraquinone anti-tumor product with a structure and anticancer effect similar to that of Doxorubicin. Due to its lack of amino sugar structure, absence of free radicals, and inhibition of lipid peroxidation, it has lower cardiac toxicity. Its mechanism of action indicates that MA can be regarded as a non-specific product for the cell cycle, as it can kill cancer cells of any cell cycle and inhibit both proliferating and non proliferating cells. The dividing cells are more sensitive to this product than the resting cells, and the S stage is the most sensitive to this product.
Are the side effects of Mitoxantrone hydrochloride severe?
Mitoxantrone HCL powder is a cell cycle nonspecific product, which has no complete cross-resistance with anthracyclines. Mitoxantrone is strongly combined with bases and embedded into DNA, causing cross-linking within and between DNA chains, leading to DNA single-strand and double-strand breaks, inhibiting the nucleic acid synthesis and leading to cell death. It can inhibit tumor cells in all cell cycles, especially in the S phase.
This product has been favored by patients once it is put on the market, but chemotherapy will have side effects. The side effects of Mitoxantrone include bone marrow suppression: leukocyte and platelet decline; Gastrointestinal reactions: nausea, vomiting, oral mucositis, diarrhea; The cardiac toxicity is lighter than adriamycin; If the liquid medicine leaks out of the blood vessel, it can show local redness, swelling and burning to feel immediately, that is, it can cause serious subcutaneous tissue necrosis. Therefore, when injecting mitoxantrone, do not let the liquid medicine leak out of the blood vessel. Mitoxantrone also has some other adverse reactions, including hair loss, decreased renal function, fatigue, hematuria, elevated creatinine, headache, and so on, which can be treated symptomatically.
The latest study of Mitoxantrone Hydrochloride liposome solution in the treatment of patients with advanced solid tumors
Mitoxantrone Hcl Powder is an anthraquinone antibiotic antitumor product. The same type of include Daunorubicin, Adriamycin, Epirubicin, Pirarubicin and Cadralazine. The main mechanism of action is to insert Deoxyribonucleic acid through another substance, cause cross-linking and fracture of DNA structure, and interfere with RNA; Mitoxantrone is also an effective inhibitor of topoisomerase II. Mitoxantrone can kill proliferative and nonproliferative cancer cells in the human body.
Mitoxantrone Hydrochloride liposome solution is a new technology. With the encapsulation of liposomes, the pharmacokinetic parameters and tissue distribution of product in vivo have changed, resulting in differences in efficacy and toxicity: for example, prolonging the maintenance time in blood, reducing the distribution of drugs in normal tissues, and increasing the accumulation in tumor tissues, so as to reduce the toxicity of drugs and enhance the therapeutic effect of product.
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS | Suitable for under 50kg. International door to door express | We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order | |
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Mitoxantrone HCL powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:Is Mitoxantrone hydrochloride the same as Doxorubicin?
The former is an Anthraquinone-type compound, and it is less toxic than the latter.
Q2: Why is Mitoxantrone hydrochloride called red death?
Because it has very serious side effects, such as causing fatal heart failure, etc. Moreover, it will also cause the urine to turn red.
Q3:What are the warnings for Mitoxantrone hydrochloride?
Mitoxantrone hydrochloride is accompanied by a black box warning, which highlights three high-risk adverse reaction risks: the possibility of inducing fatal heart failure, secondary leukemia, and severe bone marrow suppression.
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