| White to light yellow Crizotinib powder is the first accurate product of non-small cell lung cancer approved by FDA, and it is also one of the four legendary products with the fastest development in the history of tumor drug research and development. Pure Xalkori R is a multi-target tyrosine kinase inhibitor (TKI), which can be used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with Anaplastic lymphatic enzyme (ALK) |
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Items |
Standard |
Result |
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Appearance |
White or off-white crystalline powder |
Conform |
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Identification |
HPLC |
Conform |
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Infrared absorption |
Conform |
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Melting point |
190℃~192℃ |
191℃~192℃ |
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Loss on drying |
≤ 1.00 % |
0.20 % |
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Residue on ignition |
≤ 0.10 % |
0.04 % |
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Heavy metals |
≤ 10ppm |
＜ 10ppm |
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Any single impurity |
≤ 0.20 % |
0.13 % |
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Total impurities |
≤ 1.00 % |
0.47 % |
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Purity (HPLC) |
≥ 99.00 % |
99.52 % |
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| Conclusion: | The results conform with the standard | ||
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Storage: |
Keep in dry & cool place, avoid exposure to strong light |
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Which is better, Entrectinib or Crizotinib?
Firstly, Entrectinib has a wider range of anti-tumor activities. Crizotinib mainly has good inhibitory effects on ALK and ROS1 mutant lung cancer, but its efficacy is poor for other mutant lung cancer. In contrast, Entrectinib, as a multi-target inhibitor, can simultaneously inhibit lung cancer caused by ALK, ROS1, and NTRK gene mutations, making it more comprehensive in terms of anti-tumor activity.
Secondly, Entretinib powder has a relatively small impact on drug resistance. Crizotinib powder is highly effective for some patients during the initial treatment process, but over time, the tumor may gradually develop drug resistance. Entrectinib has shown good advantages in this regard, as studies have found that by inhibiting multiple targets, it can reduce the incidence of drug-resistant mutations, thereby improving the persistence of therapeutic effects.
In addition, Entrectinib also has good blood-brain barrier permeability. Lung cancer may spread to the brain and form brain metastases, which poses greater challenges to treatment. The role of Crizotinib in the treatment of brain metastases is limited because it cannot effectively cross the blood-brain barrier. However, compared to other drugs, Crizotinib has minimal damage to the brain.
In addition, Entrectinib has better safety and tolerability. Research has found that compared to Crizotinib, it does not produce serious side effects such as hepatotoxicity, nephrotoxicity, and cardiotoxicity in the treatment of lung cancer. However, Crizotinib is also well tolerated, allowing patients to complete treatment cycles more effectively and improve treatment outcomes.
In summary, Entrectinib has an advantage over 98% purity Crizotinib in the treatment of lung cancer. It has a wider range of anti-tumor activity, less impact on drug resistance, excellent blood-brain barrier permeability, and better safety and tolerability. However, this cannot replace the excellent initial performance of Crizotinib raw material and its protective effect on the human brain, which makes it the preferred product for cancer comprehensive therapy (cocktail therapy).
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| 877399-52-5 Crizotinib | 1108743-60-7 Entrectinib |
Regarding the biological activity of this product
Crizotinib is an effective c-Met and ALK inhibitor with IC50 values of 11 nM and 24 nM, respectively, in cell assays. PF-02341066 is also an effective ROS1 inhibitor with a Ki value of less than 0.025 nM. Crizotinib powder can induce autophagy in various lung cancer cell lines by inhibiting the STAT3 pathway.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Crizotinib powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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