What is Ruxolitinib Phosphate?
Ruxolitinib Phosphate Pharmaceutical Chemical Powder is a potent JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM, respectively, showing 130-fold selectivity over JAK3. Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with an EC50 of 186 nM. Ruxolitinib significantly increases apoptosis in the Ba/F3-EpoR-JAK2V617F cell system and inhibits hematopoietic progenitor proliferation in primary MPN patient samples.
|
|
| Ruxolitinib Phosphate Picture | Ruxolitinib Phosphate MF |
Ruxolitinib Phosphate Benefits
Ruxolitinib Phosphate Pharmaceutical Chemical Powder is mainly used in:
Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate form of Ruxolitinib. Ruxolitinib is the first clinically effective, selective JAK1/2 inhibitor with IC50 of 3.3nM/2.8nM in a cell-free Chemicalbook assay. Acting on JAK1, JAK2 is more than 130 times more selective than acting on JAK3. Ruxolitinib kills tumor cells via toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
Application of Ruxolitinib Phosphate
Ruxolitinib (180 mg/kg, PO) reduced tumor burden in mice vaccinated with JAK2V617F-expressing cells without causing anemia or lymphopenia.
Related Products
Nilotinib | 641571-10-0 |
Imatinib | 152459-95-5 |
Lapatinib | 231277-92-2 |
Lapatinib Ditosylate | 388082-78-8 |
Toremifene Citrate | 89778-27-8 |
Sodium dichloroacetate | 2156-56-1 |
Ribonucleic Acid | 63231-63-0 |
sorafenib tosylate | 475207-59-1 |
Dacarbazine | 4342-03-4 |
Vincristine sulfate | 2068-78-2 |
Vinorelbine Tartrate | 125317-39-7 |
Vinorelbine | 71486-22-1 |
Vinblastine | 865-21-4 |
Vinblastine Sulfate/Vinblastine Sulphate | 143-67-9 |
vincristine | 57-22-7 |
Carmustine | 154-93-8 |
Combretastatin A-4 | 117048-59-6 |
Mitomycin C | 50-07-7 |
Topotecan | 123948-87-8 |
How To Obtain Samples of Ruxolitinib Phosphate?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API powder Ruxolitinib Phosphate.
The Best Ruxolitinib Phosphate Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Ruxolitinib Phosphate?
Faithfulbio specialize in Ruxolitinib Phosphate for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
Transportation Time | Shipping method | Cargo weight requirements | Advantage |
3-7 days | DHL,Germany DHL,Germany DPD, | Suitable for under 50kg. | We have warehouses in Germany and California, the USA, |
7-15 days | By Air | Suitable for more than 50kg. | |
15-60 days | By Sea | Suitable for more than 500kg. |
kindly note: Use this compound for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Ruxolitinib Phosphate?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
Hot Tags: ruxolitinib phosphate pharmaceutical chemical powder cas 1092939-17-7, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China