What is Crebinostat ?
Crebinostat is an effective histone deacetylase (HDAC) inhibitor with multiple biological activities and effects.
| Product name | Crebinostat |
| CAS | 1092061-61-4 |
| Molecular formula | C20H23N3O3 |
| Molecular weight | 353.41 |
| EINECS Number | NA |
| melting point | NA |
| solubility | NA |
| Storage conditions | NA |
| Appearance | white powder |
| Acidity coefficient (pKa) | 9.47±0.20(Predicted) |
| Density | 1.16±0.1 g/cm3(Predicted) |
Product Specification
| Item | Specification | Results |
| Appearance | White Powder | Complies |
| Odor & taste: | Characteristic | Complies |
| Loss on drying %: | ≤6.0% | 3.83% |
| Heavy metals ppm: | <10ppm | 2.8ppm |
| As | ≤ 1.0 ppm | 0.3ppm |
| Pb | ≤ 1.0 ppm | 0.2ppm |
| Cd | ≤ 0.5 ppm | 0.1ppm |
| Microbiology: | ||
| Total Plate Count: | ≤ 1000cfu/g | 28 cfu/g |
| Yeast & Mold: | ≤ 100cfu/g | 8 cfu/g |
| E.Coli: | Negative | Complies |
| S. Aureus: | Negative | Complies |
| Salmonella: | Negative | Complies |
| Assay | 99%~101% | 99.50% |
| Conclusion | Conform with enterprise specification | |
Where is Crebinostat usually used?
Crebinostat can be used to treat peripheral T-cell lymphoma, multiple myeloma, and other diseases.In addition, it has been studied for regulating stem cell function and affecting the activity of brain-derived neurotrophic factors, as well as inhibiting iron death processes in lung adenocarcinoma.
What are the effects of Crebinostat?
The specific effects of Crebinostat include:
Enzyme inhibition effect: IC50 values for HDAC1, HDAC2, HDAC3, and HDAC6 were 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.
Gene expression regulation: can induce acetylation of histone H3 and histone H4, and enhance the expression of cAMP response element binding protein (CREB) target gene Egr1.
Neuronal synaptic changes: can increase the density of synapsin-1 punctate along dendrites in vitro neurons.
Neuroplasticity regulation: It can regulate chromatin mediated neuroplasticity and enhance memory in mice.
In vitro study results: Treatment at a concentration of 1 μ M for 24 hours can induce acetylation of AcH4K12 and AcH3K9 in mouse primary neuronal cells, upregulate Hspa1b (Hsp70) and Bdnf mRNA expression, and downregulate Mapt mRNA expression.
In vivo study results: At a dose of 25 mg/kg, intraperitoneal injection (IP) for 10 days can enhance the memory of situational fear conditioned reflex in mice and induce an increase in total acetylation of H4K12 and H3K9 in the hippocampus.
How and where to buy Crebinostat wholesale?
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Shipping method |
Cargo weight requirements |
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3-7 days |
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Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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