Product description
Erlotinib raw powder CAS 183321-74-6 is a receptor tyrosine kinase inhibitor (EGFR antagonist), a molecularly targeted therapy product. It works by competitively binding to the intracellular catalytic site of receptor tyrosine kinases with adenosine triphosphate (ATP), inhibiting phosphorylation and thus blocking downstream proliferation signaling. This inhibits the activity of ligand-dependent HER-1/EGFR in tumor cells, thereby suppressing tumor cell proliferation.
It is primarily used for first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that has failed other therapies, and in combination with Gemcitabine for the treatment of locally advanced unresected or metastatic pancreatic cancer.
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
COA
| Tests | Specifications | Results |
| Appearance | White to off-white,crystalline powder | Complies |
| dentification(HPLC) | Conforms to Reference Standard | Complies |
| Assay(by HPLC) | 98.5%-101.5%(on anhydrous basis) | 99.8% |
| Related Substances | Individual impurity≤0.50% | 0.05% |
| Total Impurities≤2.0% | 0.15% | |
| Water(Karl Fischer) | <1.0% | 0.4% |
| Residue on lgnition | <0.1% | 0.05% |
| Heavy Metals | <20 ppm | <10 ppm |
| Chromatographic Purity | Main peak area≥99.0%of total peak area. | 99.78% |
| Sulfated Ash | <0.1% | 0.04% |
| Microbial Limits | Total Plate Count<1000cfu/g | <100cfu/g |
| Yeast &Moulds<100cfu/g | <10cfuv/g | |
| E.Coli Negative | Negative | |
| Salmonella Negative | Negative | |
| Conclusion | Conform with enterprise specification | |
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
Density: 1.2 ± 0.1 g/cm³
Boiling point: 553.6 ± 50.0 °C at 760 mmHg
Melting point: 223 - 228 °C
Molecular formula: C22H23N3O4
Molecular weight: 393.436
Flash point: 288.6 ± 30.1 °C
Precise mass: 393.168854
PSA: 74.73000
LogP: 2.39
Hepatotoxicity of Erlotinib raw powder CAS 183321-74-6
Elevated serum transaminases are common during Erlotinib treatment for pancreatic and lung cancer, with an increase in levels exceeding five times the upper limit of normal in about 10% of patients. However, the incidence of elevated serum alanine aminotransferase (ALT) levels is comparable to that observed during similar antitumor treatments. These abnormalities are usually asymptomatic and self-limiting, but dosage adjustments may be necessary. Furthermore, a limited number of reports suggest that Erlotinib treatment may be associated with clinically significant liver injury. Onset typically occurs within days or weeks of treatment, and the severity of liver damage may be considerable. Liver injury can be rapid, with elevated serum enzyme levels often indicating hepatocellular damage. Immune hypersensitivity symptoms (rash, fever, and eosinophilia) are uncommon, and autoantibody synthesis has not been reported. Regular liver function tests are recommended during treatment.
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
why choose us
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
FAQ
01. What are the common adverse reactions of Erlotinib raw powder CAS 183321-74-6?
Common adverse reactions are mostly mild to moderate, including:
Skin reactions: rash, acne-like lesions, mostly appearing on the face and trunk. These can be relieved by keeping the skin clean and avoiding scratching.
Gastrointestinal reactions: diarrhea. Mild diarrhea can be relieved by adjusting the diet (avoiding raw, cold, and spicy foods). Moderate to severe diarrhea requires immediate medical attention.
Others: stomatitis, fatigue, mild abnormalities in liver function, etc.
If severe adverse reactions occur (such as severe rash, severe diarrhea, or significantly abnormal liver function), immediate medical attention is required.
02. How stable is Erlotinib raw powder CAS 183321-74-6? What precautions should be taken when storing it?
Erlotinib is relatively sensitive to light and humidity, and is prone to degradation during long-term storage. Storage precautions are as follows:
Packaging: Double-sealed packaging, with an inner layer of vacuum-sealed aluminum foil bag and an outer layer of moisture-proof cardboard box;
Environment: Store in a cool, dry place, with a temperature controlled between 2–8℃ and a relative humidity ≤60%, avoiding direct sunlight;
Shelf life: Under the specified storage conditions, the shelf life is usually 24 months. Regular stability testing of the stocked products is necessary.
03. Where can I buy Erlotinib raw powder CAS 183321-74-6?
Hot Tags: erlotinib raw powder cas 183321-74-6, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China