Trilostane Raw Powder CAS 13647-35-3

Trilostane raw powder is an inhibitor of 3 β- hydroxysteroid dehydrogenase, which can be used for Cushing's syndrome. Density: 1.3±0.1 g/cm3, boiling point: 497.8 45.0 C at 760mmhg, melting point: 264ºC, molecular formula: C20H27NO3, molecular weight: 329.433. It is a white crystalline powder.

Trilostane is a new anti-estrogen drug with a new mechanism of action, which can reduce the formation of all endogenous steroids, including estrogen and androgen. Since it was approved for marketing, some scholars have studied its effect on postmenopausal women with advanced breast cancer, and there have been effective reports of small-scale trials.

In August 2002, for the first time in the UK, Trilostane officially obtained a new and important indication for the treatment of postmenopausal women's progressive breast cancer.

How does Trilostane work?

Breast cancer is a hormone-dependent tumor, and estrogen is the main driving factor for the growth of this cancer cell. Therefore, one of the main modern therapies for breast cancer is targeted estrogen, which can block the effect of estrogen by inhibiting estrogen production or its action site, namely the estrogen receptor. It used to be thought that the estrogen receptor was only a single receptor, but recent studies have identified that it has at least two subtypes, α, and β. Among them, the combination of estrogen with α -estrogen receptor can stimulate cell growth, but the combination with β -estrogen receptor can down-regulate α -estrogen receptor and slow down cell proliferation rate. Studies have revealed that Trolostan can not only reduce the production of estrogen but also regulate the binding of estrogen to different subtypes of estrogen receptors. At the same time, it shows the dual effects of α -estrogen receptor inhibitor and β -estrogen receptor agonist, and finally blocks and changes the negative effects of estrogen on cancer cells. Trilostane Raw Powder is a unique mode of action not only distinguishes it from other existing anti-estrogen drugs but also is the pharmacological basis of its still highly effective treatment of failed or drug-resistant breast cancer after other anti-estrogen therapies.

In vitro study of Trilostane

Tristane and 4-Hydroxytamoxifen(OHT) both affect the transcription of genes involved in cell cycle regulation, cell adhesion, and matrix formation. However, only 12.5% of the down-regulated genes and 9.2% of the up-regulated genes of Tristane are similar to those in MCF-7 cells.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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