Product description
BGJ-398 CAS 872511-34-7 is a small-molecule targeted intervention designed to address specific gene abnormalities. Its core action targets the fibroblast growth factor receptor (FGFR) family, exhibiting highly selective inhibitory activity against FGFR1, FGFR2, and FGFR3. By precisely blocking the ATP binding site of the receptor, it inhibits kinase activity and autophosphorylation, thereby interrupting downstream abnormal signaling pathways such as Ras-MAPK and PI3K-Akt. This effectively curbs the excessive proliferation of abnormal cells, induces cell cycle arrest and apoptosis, providing an important precision intervention option for patients with solid tumors exhibiting specific gene mutations.
Infigratinib selectively binds to and inhibits FGFR activity, blocking downstream signaling cascades and inducing tumor cell death by progressively reducing cancer cell proliferation. It is indicated for the treatment of previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with fibroblast growth factor receptor 2 (FGFR2) fusion in adult patients.
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COA
| Tests | Specifications | Results |
| Appearance | Off white or yellow powder | Complied |
| Identification by NMR |
Conforms to the reference spectrum |
Complied |
| Identification by IR | IR:The IR absorption of the sample must beconcordant with Test Sandard |
Complied |
| Purity | NLT 98% | 99.5% |
| Residue on ignition | NMT 0.2% | 0.1% |
| Water by KF | NMT 1% | 0.2% |
| Conclusion | Conform with enterprise specification | |
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Density: 1.4±0.1 g/cm³
Boiling Point: 747.9±60.0 °C at 760 mmHg
Molecular Formula: C₂₆H₃₁Cl₂N₇O₃
Molecular Weight: 560.475
Flash Point: 406.1±32.9 °C
Exact Mass: 559.186523
PSA: 98.58000
LogP: 5.03
Vapor Pressure: 0.0±2.5 mmHg at 25°C
Refractive Index: 1.654
Storage Conditions: -20°C
Mechanism of Action of BGJ-398 CAS 872511-34-7
Infigratinib exerts its effects at the biochemical and cellular levels by highly selectively inhibiting the activity of FGFR1, FGFR2, FGFR3, and FGFR4. Activation of the FGFR pathway is associated with the proliferation of malignant cancer cells; therefore, inhibition of FGFR-specific kinases can effectively reduce tumor cell proliferation.
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Our Factory
Package
Shipping Methods
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. What is the mechanism of action of BGJ-398 CAS 872511-34-7?
It works by binding to the ATP receptor site, blocking kinase activation and signal transduction, inhibiting abnormal cell proliferation, and regulating the cell cycle.
02. What are the most common bodily reactions to BGJ-398 CAS 872511-34-7?
The most common reaction is elevated blood phosphorus levels. Other possible symptoms include visual discomfort, oral mucosal discomfort, fatigue, hair loss, gastrointestinal discomfort, and decreased appetite.
03. Where can I buy BGJ-398 CAS 872511-34-7?
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