99% Raw Material Ruxolitinib Powder CAS 941678-49-5

99% Raw Material Ruxolitinib Powder is the first oral drug approved by FDA to treat bone marrow fibrosis. It is a tyrosine kinase inhibitor, that is, a small molecule inhibitor of protein kinases Jak1 and JAK2. It is suitable for the treatment of intermediate or high-risk bone marrow fibrosis, including primary bone marrow fibrosis, bone marrow fibrosis after polycythemia vera, and bone marrow fibrosis after primary thrombocytopenia. At present, ruxolitinib has been approved by more than 50 countries around the world, including the European Union, Canada, and some Asian, Latin American, and South American countries. European and American countries have granted ruxolitinib as an orphan drug for the treatment of bone marrow fibrosis.

What is myelofibrosis?

Bone marrow fibrosis is called MF for short. It is a myeloproliferative disease caused by collagen proliferation in bone marrow hematopoietic tissue and its fibrous tissue seriously affecting hematopoietic function. Primary myelofibrosis is also known as Myelosclerosis and Unexplained myeloid metaplasia. The disease has different degrees of bone marrow fibrous tissue hyperplasia, and extramedullary hematopoiesis mainly in the spleen, followed by liver and lymph nodes. The typical clinical manifestations are juvenile erythrocytic and granulocytic anemia, with more teardrop-like erythrocytes. Dry pumping often occurs in bone marrow puncture, obvious enlargement of the spleen, and varying degrees of osteosclerosis. This disease is a rare disease with an incidence rate of 0.2/100000 to 2/100000. The onset age is mostly between 50 and 70 years old, which can also be seen in infants, and men are slightly higher than women.

How do deal with such symptoms?

As a kinase inhibitor, it is a specific product for the treatment of intermediate or high-risk bone marrow fibrosis. Incb18424 is Jak1 and JAK2 tyrosine kinase inhibitor (IC50 2.7 and 4.5 nm, respectively), with potent antitumor and immunomodulatory activities. Ruxolitinib inhibited IL-6 signal (IC50 = 281nm) and JAK2V617F + BA / F3 cell proliferation (IC50 = 127nm). 99% Raw Material Ruxolitinib Powder can also inhibit STAT3 phosphorylation in wild-type JAK2 and JAK2V617F mutant patients. Clinically, it can significantly reduce the level of circulating inflammatory cytokines. Ruxolitinib plays an effective role in adjuvant arthritis and multiple rat arthritis models.

What are the latest research results on this product?

Columbia University Medical Center conducted a study to test whether a drug approved to treat bone marrow diseases can help people get rid of alopecia areata. The study found that most of the seven women and five men who took part in the human test improved significantly after taking one of the drugs, ruxolitinib. In September 2021, ruxolitinib cream was approved in the United States for medical use in the treatment of mild to moderate atopic dermatitis (AD). It is the first external Janus kinase inhibitor approved in the United States.

In the United States, 99% Raw Material Ruxolitinib Powder is also suitable for the treatment of steroid-refractory acute graft-versus-host disease and chronic graft-versus-host disease in people aged 12 and over. At the same time, this product is used to treat people with polycythemia vera who are resistant or intolerant to hydroxyurea.

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