Sirolimus powder is a novel macrocyclic lactone immunosuppressant. The pure product is a white solid crystal with a melting point of 183-185 ℃. It is lipophilic and can be dissolved in organic solvents such as methanol, ethanol, acetone, chloroform, etc. However, the color of the solution may darken during storage. Extremely soluble in water, almost insoluble in ether. In clinical practice, this product can maintain the immune function of transplanted organs (especially kidney transplantation) to slow down immune rejection reactions after organ transplantation surgery. However, in the latest research, scientists have found that using Rapamycin raw materials on mouse patients can restore memory deficits, which may be a new direction for the future treatment of Alzheimer's disease (senile dementia).
| Molecular formula |
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Item |
Standard |
Test Results |
|
Description |
off-white to yellow crystalline powder |
Complies |
|
Identification |
The IR spectrum of Potassium Bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard |
Complies
|
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The UV spectrum of 95% Ethanol preparation of the sample exhibits maxima at 267nm, 277nm, 288nm that of similar preparation of in-house reference standard. |
Complies |
|
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The retention times of the peaks for the Trans- and Cis-stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the Assay |
Complies |
|
|
Loss on drying |
≤0.5% |
0.16% |
|
Heavy metal |
≤0.002% |
Complies |
|
Total impurity |
≤2.0% |
0.76% |
|
Single impurity |
≤1.0% |
0.67% |
|
Cis-stereoisomer of Sirolimus |
≤5.0% |
2.4% |
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Assay |
≥98.0% |
99.2% |
| Conclusion： |
Conform with enterprise specification . |
What are the action principles of this product?
Rapamycin (also known as "sirolimus") was first discovered by scientists in 1975 as a secondary metabolite secreted from Streptomyces hygroscopicus. Its chemical structure belongs to the "tricyclic lactone class" compounds. Similar in structure to Tacrolimus, but with very different immunosuppressive mechanisms. We know that Tacrolimus inhibits the proliferation of T lymphocytes from G0 phase to G1 phase. Compared with FK506, RAPA can block calcium dependent and non calcium dependent signaling pathways of T lymphocytes and B lymphocytes. At the same time, Rapamycin powder is easily broken down by enzymes after entering the digestive tract, and grapefruit juice contains a large amount of furan coumarins, which can inhibit the destructive effect of digestive enzymes on Sirolimus powder, thus improving its bioavailability. At present, this research result has been accepted and utilized by doctors in European and American countries in the treatment process of patients.
What are the studies on this product in cancer treatment?
Cancer cell proliferation consumes a lot of nutrients and energy from the body, and the mTOR pathway plays an important role in cell proliferation and energy metabolism. Cancer research has found that mTORC1 is abnormally activated and abnormally increased in many cancer patients, leading to abnormal conduction pathways and inducing a variety of diseases. Therefore, researchers believe that inhibiting mTOR will make cancer treatment and recovery possible. In clinical applications, rapamycin derivatives such as temsirolimus and everolimus have been used clinically to treat advanced renal cell carcinoma, especially everolimus has excellent effects in the treatment of pancreatic neuroendocrine tumors and advanced breast cancer. In addition, there are many clinical trials evaluating Sirolimus derivatives for the treatment of other cancers. In general, the anti-cancer effect of rapamycin derivatives is mainly reflected in solid tumors. The basis for the treatment of tumors is mainly because this product is a targeted inhibitor of mTOR, so as long as the tumors or other diseases closely related to this pathway (such as LAM (lymphangioleiomyomatosis) and TSC (tuberous sclerosis)) can be treated.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Sirolimus powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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