What is Alvespimycin?
Headquartered in Xi'an, the historic origin of the ancient Silk Road, Xi'an Faithful BioTech Co., Ltd. takes full advantage of the city's robust logistics and chemical industrial resources to develop into a comprehensive fine chemical supplier serving clients worldwide. Alvespimycin is a semi-synthetic benzoquinone small molecule compound derived from the natural geldmycin backbone. Its free base corresponds to the designation 467214-20-6. Its hydrochloride form is the more widely used variant in research settings. It presents as a fine powder, with the free base being a light purple powder, while the hydrochloride layer forms a dark purple-black texture. This substance is a highly effective molecule targeting the heat shock protein HSP90. In the free system, its target-binding activity reaches 62 nM. It competitively occupies the ATP-binding region within the HSP90 protein, directly blocking the core function of this molecular chaperone in assisting intracellular protein folding and stable transport. As a result, many intracellular signaling proteins related to proliferation and inflammation regulation lose structural support and are gradually broken down and cleared via the ubiquitination pathway. Simultaneously, the cell compensates by increasing HSP70 expression; this characteristic is often used as a marker for observing the effects within the system.
Application of Alvespimycin
Compared to 17-AAG modified from the same parent nucleus, this substance significantly enhances its hydrophilicity by introducing a dimethylaminoethyl side chain, resulting in more uniform distribution and a longer retention period within biological tissues. It exhibits significant regulatory effects on various abnormally proliferating cell models and can act on dozens of key signaling vectors, including HER2, AKT, mutant p53, and JAK. Currently, this substance is only available as a laboratory standard reagent, widely used in basic research such as cell signaling pathway analysis, validation of protein chaperone target mechanisms, and screening of multi-component synergistic systems. Related research covers multiple areas, including solid cell models, blood cell models, and inflammatory injury models. Past multi-stage biological exploration experiments have accumulated comprehensive in vitro and in vivo observational data for the structural optimization and scope expansion of similar backbone derivatives, making it a representative pioneering small molecule tool in the field of heat shock protein research.
COA
| Test Item | Specification | Test Result |
| Appearance | Purple to dark purple powder |
Complies |
| Purity(HPLC) | ≥98.0% | 98.65% |
| Molecular Weight | 616.75 | 616.72 |
| Solubility | Soluble in DMSO,Methanol | Complies |
| Storage Condition | -20℃,Sealed,Away from light |
Complies |
| Loss on Drying | ≤0.5% | 0.21% |
| Heavy Metal | ≤10ppm | Conforms |
| Conclusion | Conform with enterprise specification | |
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Density: 1.2±0.1 g/cm³
Boiling point: 810.5±65.0 °C at 760 mmHg
Molecular formula: C32H48N4O8
Molecular weight: 616.745
Flash point: 444.0±34.3 °C
Exact mass: 616.347229 g
PSA: 169.52000 g
LogP: 2.07 g
Mechanism of action of Alvespimycin
Alvespimycin targets and binds to the molecular chaperone protein HSP90, occupying its internal binding site and blocking its chaperone activity.
Unsupported signaling regulatory proteins become less stable and are degraded via endogenous cellular degradation pathways.
It blocks multiple signaling pathways related to cell proliferation and abnormal activation, inhibiting excessive cell proliferation and migration.
It stimulates compensatory expression of HSP70, which can serve as a marker for assessing the effects of molecular action.
It induces cell cycle arrest, promoting programmed apoptosis in abnormally proliferating cells.
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Our Factory
Package
Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What is the core target of alvespimycin?
The core target is the heat shock protein 90 (HSP90) molecular chaperone.
02. How does alvespimycin inhibit target function?
Alvespimycin competitively binds to the ATP-binding region within the target, directly blocking its function in stabilizing the folding of accessory proteins.
03. What changes occur in cells after target function is blocked?
Degradation of proliferation-related signaling proteins, cell cycle arrest, and programmed apoptosis in abnormal cells.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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