Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.
Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.
Introduction to Irinotecan
API Irinotecan powder is a semi-synthetic, water-soluble camptothecin derivative. Both the drug itself and its metabolite, SN-38, act as DNA topoisomerase I inhibitors. The complexes they form with topoisomerase I and DNA induce single-strand DNA breaks, thereby blocking DNA replication and inhibiting RNA synthesis; this action is cell-cycle specific, primarily targeting cells in the S phase. Irinotecan is primarily used to treat colorectal cancer and small-cell carcinoma; it may also be used in combination with 5-fluorouracil and folic acid to treat pancreatic cancer following the failure of first-line therapy.
| Molecular formula |  | |
| Test items | Specifications | Results |
| Appearance | White to off-white crystalline powder | Complies |
| Identification | IR ,HPLC | Complies |
| Optical rotation | -94 °~ - 102 ° | -99 ° |
| PH | 8.0~ 10.0 | 8.5 |
| Crystallinity | Complies | Complies |
| Water | ≤2.0% | 0.8% |
| Residue on ignition | ≤0.2% | 0.08% |
| Heavy metals | ≤20ppm | Complies |
| Residual solvent | Methanol ≤ 3000 ppm Ethanol ≤ 5000 ppm Methylene chloride ≤ 600 ppm | ND |
| Organic Impurities | Any individual impurity ≤ 1.0% Any unknown individual impurity ≤ 0. 10% Impurities exceed 0.4% ≤ 4 Total impurities ≤ 3.5% | ＜1.0% ND 1 1.8% |
| Assay(HPLC) | 96.5%~ 102.0%(on anhydrous) | 98.5% |
| Conclusion | Conform with the enterprise standard | |
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What are the uses of irinotecan?
API Irinotecan powder is often used in the treatment of metastatic colon (rectum) cancer, which is difficult to be effective with traditional therapy. This product and combined with 5-fluorouracil and calcium folinate in the treatment of patients with advanced colorectal cancer who had not received chemotherapy before; As a single product, it is used to treat patients with advanced colorectal cancer who have failed to receive chemotherapy containing 5-fluorouracil. Irinotecan hydrochloride can also be used in lung cancer, breast cancer, gastric cancer, pancreatic cancer, cervical cancer, ovarian cancer, etc.
What is the mechanism of action of irinotecan?
API Irinotecan Powder is a topoisomerase I inhibitor precursor compound. Its action begins in the liver where it is converted into the metabolite SN-38, which is approximately 1000 times more active than the original compound. This active substance forms a stable ternary complex with topoisomerase I and DNA, reversibly blocking the reconnection of single-strand breaks induced by topoisomerase I, thereby converting originally repairable single-strand damage into stable covalent complexes. When DNA replication enzymes encounter this complex during replication, it causes replication fork collisions and leads to fatal DNA double-strand breaks, which are difficult to repair and thus cause the cell cycle to stall at the S-G2 phase and trigger apoptosis, ultimately achieving the anti-tumor effect. Additionally, this process is influenced by the UGT1A1 enzyme metabolism, and the genetic polymorphism of this enzyme can lead to differences in the accumulation of active metabolites, requiring vigilance against individual toxicity risks.
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS | Suitable for under 50kg. International door to door express | We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order | |
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide API Irinotecan Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Click :email :sales6@faithfulbio.com Or WhatsApp :+86 17782780648
FAQ:
Q1:Why do different individuals exhibit significant differences in the toxicity of Irinotecan?
The UGT1A1 enzyme in the body is responsible for the metabolic clearance of SN-38. There are genetic polymorphisms in this enzyme in the human population, and different metabolic abilities will cause different levels of accumulation of active products.
Q2:What are the primary applications of Irinotecan API powder?
It is mainly used for handling tumor-related pharmacological experiments and formulation research. At the same time, it can also be used as a control standard substance to conduct basic research on compound metabolism and individual toxicity differences.
Q3:What are the common adverse reactions caused by Irinotecan?
Gastrointestinal reactions-including severe diarrhea, nausea, vomiting, and abdominal discomfort-are the most common adverse effects; bone marrow suppression is the next most frequent, manifesting as a decrease in neutrophil counts and weakened immune resistance.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
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