Female Hormone Powder Estradiol Benzoate CAS 50-50-0

Female Hormone Powder Estradiol Benzoate is an analog of estradiol, which contains benzyl ester at position C-3. Estradiol benzoate can be used to treat the damage caused by the reduction of estrogen production in the body. In terms of biological activity, this product can be compared with human, mouse, and chicken er α Combined, IC50 range 22-28nm.

What is the relevant research on this product?

Estrogens guide the development of female genes in embryonic development and adolescence. It is also the main estrogen secreted by premenopausal ovaries. Female Hormone Powder Estradiol Benzoate is a synthetic ester because it contains a benzyl ester at the C-3 position and is often used in combination with progesterone to induce estrus in livestock. The compound is associated with human and mouse estrogen receptors α (ER α), And ER binding in chickens, with IC50 values ranging from 22 to 28 nm. The above data can show that the affinity of this product is reduced by 6-10 times compared with estradiol.

What should we pay attention to when using this product?

The adverse reactions of the Female Hormone Powder Estradiol Benzoate may include nausea, headache, breast pain, occasional thromboembolism, rash, water, sodium retention, etc. Therefore, a gynecological examination shall be carried out regularly during medication. Use with caution in patients with hysteromyoma, heart disease, epilepsy, diabetes, and hypertension; Severe liver and kidney dysfunction are forbidden for patients with breast cancer and pregnant women. Shake well before use or heat up. Children's medication is easy to causes precocious puberty and should be banned. When combined with hypoglycemic drugs, its hypoglycemic effect may be weakened, and the dose should be adjusted. The above contents are only for the introduction. The use of drugs must be carried out under the guidance of doctors in regular hospitals

Is this product the same as estradiol?

The effect of Estradiol benzoate powder is the same as that of estradiol. It can make the endometrium proliferate, enhance the contraction of uterine smooth muscle, and promote the development and proliferation of mammary glands: a large dose can inhibit the release of prolactin, resist the effect of androgen, and increase the deposition of calcium in bone. Clinically, it is mainly used to supplement estrogen deficiency, such as atrophic vaginitis, vaginal dryness, female gonadal dysfunction, vulvar dryness, menopausal vasomotor symptoms, ovariectomy, and primary ovarian failure, etc. Amenorrhea, menopausal syndrome, withdrawal of milk, and prostate cancer. This product is mainly metabolized in the liver and decomposed into estradiol. Part of it binds to sex hormone-binding globulin (SHBG), and the unbound free part binds to the target tissue and estrogen receptor, producing estrogen effect through transcription and protein synthesis. In the liver or kidney, estrogen combines with glucuronic acid or sulfate group to become a water-soluble salt and is quickly discharged from the kidney.

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